SETD5

SET domain containing 5
Identifiers
Symbol	SETD5
External IDs	OMIM: 615743 HomoloGene: 12485 GeneCards: SETD5 Gene
Gene ontology Molecular function • protein binding Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55209	72895
Ensembl	ENSG00000168137	ENSMUSG00000034269
UniProt	Q9C0A6	Q5XJV7
RefSeq (mRNA)	NM_001080517	NM_028385
RefSeq (protein)	NP_001073986	NP_082661
Location (UCSC)	Chr 3: 9.4 – 9.48 Mb	Chr 6: 113.08 – 113.15 Mb
PubMed search

SET domain containing 5 is a protein that in humans is encoded by the SETD5 gene. ^[1]

Model organisms

Model organisms have been used in the study of SETD5 function. A conditional knockout mouse line called Setd5^{tm1a(EUCOMM)Wtsi} was generated at the Wellcome Trust Sanger Institute.^[2] Male and female animals underwent a standardized phenotypic screen^[3] to determine the effects of deletion.^[4][5][6][7] Additional screens performed: - In-depth immunological phenotyping^[8]

Setd5 knockout mouse phenotype

Characteristic	Phenotype
All data available at.[3][8]
Insulin	Normal
Homozygous viability at P14	Abnormal
Recessive lethal study	Abnormal
General Observations	Abnormal
Body weight	Abnormal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Abnormal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Abnormal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Abnormal
Micronucleus test	Abnormal
Heart weight	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Bone Marrow Immunophenotyping	Normal
Epidermal Immune Composition	Normal

References

1. "Entrez Gene: SET domain containing 5". Retrieved 2013-10-07.
2. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
3. "International Mouse Phenotyping Consortium".
4. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
5. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
6. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
7. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
8. "Infection and Immunity Immunophenotyping (3i) Consortium".