SETD8

SET domain containing (lysine methyltransferase) 8
PDB rendering based on 1zkk.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZKK​, 2BQZ​, 3F9W​, 3F9X​, 3F9Y​, 3F9Z​, 4IJ8​
Identifiers
Symbols	SETD8 ; KMT5A; PR-Set7; SET07; SET8
External IDs	OMIM: 607240 MGI: 1915206 HomoloGene: 41372 IUPHAR: 2704 ChEMBL: 1795176 GeneCards: SETD8 Gene
EC number	2.1.1.43
Gene ontology Molecular function • p53 binding • transcription corepressor activity • protein binding • protein-lysine N-methyltransferase activity • histone-lysine N-methyltransferase activity Cellular component • nucleus • nucleoplasm • chromosome • nucleolus Biological process • negative regulation of transcription from RNA polymerase II promoter • mitotic cell cycle • chromatin organization • transcription, DNA-templated • mitotic nuclear division • peptidyl-lysine monomethylation • histone lysine methylation • regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of transcription, DNA-templated • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	387893	67956
Ensembl	ENSG00000183955	ENSMUSG00000049327
UniProt	Q9NQR1	Q2YDW7
RefSeq (mRNA)	NM_020382	NM_030241
RefSeq (protein)	NP_065115	NP_084517
Location (UCSC)	Chr 12: 123.38 – 123.41 Mb	Chr 5: 124.44 – 124.46 Mb
PubMed search

Histone-lysine N-methyltransferase SETD8 is an enzyme that in humans is encoded by the SETD8 gene.^[1][2][3][4]

References

1. Couture JF, Collazo E, Brunzelle JS, Trievel RC (Jun 2005). "Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase". Genes Dev 19 (12): 1455–65. doi:10.1101/gad.1318405. PMC 1151662. PMID 15933070.
2. Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D (Jun 2002). "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin". Mol Cell 9 (6): 1201–13. doi:10.1016/S1097-2765(02)00548-8. PMID 12086618.
3. Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y (Jul 2002). "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase". Curr Biol 12 (13): 1086–99. doi:10.1016/S0960-9822(02)00924-7. PMID 12121615.
4. "Entrez Gene: SETD8 SET domain containing (lysine methyltransferase) 8".

Further reading

• Mizzen CA, Yang XJ, Kokubo T, et al. (1997). "The TAF(II)250 subunit of TFIID has histone acetyltransferase activity.". Cell 87 (7): 1261–70. doi:10.1016/S0092-8674(00)81821-8. PMID 8980232.
• Rice JC, Nishioka K, Sarma K, et al. (2002). "Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.". Genes Dev. 16 (17): 2225–30. doi:10.1101/gad.1014902. PMC 186671. PMID 12208845.
• Schlisio S, Halperin T, Vidal M, Nevins JR (2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.". EMBO J. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Xiao B, Jing C, Wilson JR, et al. (2003). "Structure and catalytic mechanism of the human histone methyltransferase SET7/9.". Nature 421 (6923): 652–6. doi:10.1038/nature01378. PMID 12540855.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Xiao B, Jing C, Kelly G, et al. (2005). "Specificity and mechanism of the histone methyltransferase Pr-Set7.". Genes Dev. 19 (12): 1444–54. doi:10.1101/gad.1315905. PMC 1151661. PMID 15933069.
• Yin Y, Liu C, Tsai SN, et al. (2005). "SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20.". J. Biol. Chem. 280 (34): 30025–31. doi:10.1074/jbc.M501691200. PMID 15964846.
• Shi X, Kachirskaia I, Yamaguchi H, et al. (2007). "Modulation of p53 function by SET8-mediated methylation at lysine 382.". Mol. Cell 27 (4): 636–46. doi:10.1016/j.molcel.2007.07.012. PMC 2693209. PMID 17707234.