SFRS11

Serine/arginine-rich splicing factor 11
Identifiers
Symbols	SRSF11 ; NET2; SFRS11; dJ677H15.2; p54
External IDs	OMIM: 602010 MGI: 1916457 HomoloGene: 36164 GeneCards: SRSF11 Gene
Gene ontology Molecular function • nucleotide binding • protein binding • poly(A) RNA binding Cellular component • nucleus • nucleoplasm Biological process • mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • mRNA processing • mRNA export from nucleus • RNA splicing • gene expression • mRNA 3'-end processing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9295	69207
Ensembl	ENSG00000116754	ENSMUSG00000055436
UniProt	Q05519	E9Q6E5
RefSeq (mRNA)	NM_001190987	NM_001093752
RefSeq (protein)	NP_001177916	NP_001087221
Location (UCSC)	Chr 1: 70.21 – 70.25 Mb	Chr 3: 158.01 – 158.04 Mb
PubMed search

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.^[1][2]

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.^[2]

Interactions

SFRS11 has been shown to interact with U2AF2.^[3]

References

1. Chaudhary N, McMahon C, Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A 88 (18): 8189–93. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.
2. "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
3. Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. (UNITED STATES) 16 (10): 5400–8. ISSN 0270-7306. PMC 231539. PMID 8816452.

Further reading

• Zhang WJ, Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. PMC 231539. PMID 8816452.
• Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". J. Biol. Chem. 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
• Page-McCaw PS, Amonlirdviman K, Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity". RNA 5 (12): 1548–60. doi:10.1017/S1355838299991938. PMC 1369877. PMID 10606266.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
• Wu JY, Kar A, Kuo D, et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMC 1592875. PMID 16943417.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.