SFRS3

Serine/arginine-rich splicing factor 3
Rendering based on PDB 2I2Y​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2I2Y​, 2I38​
Identifiers
Symbols	SRSF3 ; SFRS3; SRp20
External IDs	OMIM: 603364 MGI: 98285 HomoloGene: 55708 GeneCards: SRSF3 Gene
Gene ontology Molecular function • nucleotide binding • RNA binding • protein binding • phospholipase binding • poly(A) RNA binding Cellular component • nucleoplasm • cytoplasm • nuclear speck Biological process • mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • mRNA export from nucleus • RNA splicing • gene expression • mRNA 3'-end processing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6428	20383
Ensembl	ENSG00000112081	ENSMUSG00000071172
UniProt	P84103	P84104
RefSeq (mRNA)	NM_003017	NM_013663
RefSeq (protein)	NP_003008	NP_038691
Location (UCSC)	Chr 6: 36.59 – 36.61 Mb	Chr 17: 29.03 – 29.04 Mb
PubMed search

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.^[1][2]

Browser View

UCSC Genome Browser View

UCSC Gene details page

Interactions

SFRS3 has been shown to interact with RBM7.^[3]

References

1. Zahler AM, Lane WS, Stolk JA, Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
2. "Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3".
3. Guo, Taylor B; Boros Laszlo G; Chan Kam C; Hikim Amiya P Sinha; Hudson Alan P; Swerdloff Ronald S; Mitchell Aaron P; Salameh Wael A (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. (United States) 24 (2): 204–14. ISSN 0196-3635. PMID 12634307.

Further reading

• Ayane M, Preuss U, Köhler G, Nielsen PJ (1991). "A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs.". Nucleic Acids Res. 19 (6): 1273–8. doi:10.1093/nar/19.6.1273. PMC 333853. PMID 2030943.
• Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle.". Nature 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
• Cáceres JF, Screaton GR, Krainer AR (1998). "A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm.". Genes Dev. 12 (1): 55–66. doi:10.1101/gad.12.1.55. PMC 316398. PMID 9420331.
• Zhang WJ, Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.". Mol. Cell. Biol. 18 (2): 676–84. PMC 108778. PMID 9447963.
• Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex.". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
• Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
• Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.
• Shnyreva M, Schullery DS, Suzuki H, et al. (2000). "Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein.". J. Biol. Chem. 275 (20): 15498–503. doi:10.1074/jbc.275.20.15498. PMID 10809782.
• Elliott DJ, Bourgeois CF, Klink A, et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection.". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. doi:10.1073/pnas.97.11.5717. PMC 18499. PMID 10823932.
• Huang Y, Steitz JA (2001). "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA.". Mol. Cell 7 (4): 899–905. doi:10.1016/S1097-2765(01)00233-7. PMID 11336712.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins.". RNA 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Guo TB, Boros LG, Chan KC, et al. (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors.". J. Androl. 24 (2): 204–14. PMID 12634307.
• Tai HH, Geisterfer M, Bell JC, et al. (2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.". Biochem. Biophys. Res. Commun. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. PMID 12890497.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.". J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.