SFRS5

Serine/arginine-rich splicing factor 5
Identifiers
Symbols	SRSF5 ; HRS; SFRS5; SRP40
External IDs	OMIM: 600914 HomoloGene: 134432 GeneCards: SRSF5 Gene
Gene ontology Molecular function • nucleotide binding • protein binding • poly(A) RNA binding • RS domain binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • nuclear speck Biological process • mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • mRNA splice site selection • mRNA processing • mRNA export from nucleus • RNA splicing • response to wounding • gene expression • mRNA 3'-end processing • regulation of cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6430	20384
Ensembl	ENSG00000100650	ENSMUSG00000021134
UniProt	Q13243	O35326
RefSeq (mRNA)	NM_001039465	NM_001079694
RefSeq (protein)	NP_001034554	NP_001073162
Location (UCSC)	Chr 14: 69.73 – 69.77 Mb	Chr 12: 80.95 – 80.95 Mb
PubMed search

Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.^[1][2]

References

1. Diamond RH, Du K, Lee VM, Mohn KL, Haber BA, Tewari DS, Taub R (Aug 1993). "Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing". J Biol Chem 268 (20): 15185–92. PMID 7686911.
2. "Entrez Gene: SFRS5 splicing factor, arginine/serine-rich 5".

Further reading

• Zahler AM, Lane WS, Stolk JA, Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors.". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
• Screaton GR, Cáceres JF, Mayeda A, et al. (1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". EMBO J. 14 (17): 4336–49. PMC 394518. PMID 7556075.
• Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Snow BE, Heng HH, Shi XM, et al. (1997). "Expression analysis and chromosomal assignment of the human SFRS5/SRp40 gene". Genomics 43 (2): 165–70. doi:10.1006/geno.1997.4794. PMID 9244433.
• Du K, Taub R (1998). "Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes". Gene 204 (1–2): 243–9. doi:10.1016/S0378-1119(97)00552-0. PMID 9434190.
• Blencowe BJ, Issner R, Nickerson JA, Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
• Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Guil S, Gattoni R, Carrascal M, et al. (2003). "Roles of hnRNP A1, SR Proteins, and p68 Helicase in c-H-ras Alternative Splicing Regulation". Mol. Cell. Biol. 23 (8): 2927–41. doi:10.1128/MCB.23.8.2927-2941.2003. PMC 152554. PMID 12665590.
• Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cell. Dev. Biol. Anim. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC 3225227. PMID 12762840.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Ropers D, Ayadi L, Gattoni R, et al. (2004). "Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA". J. Biol. Chem. 279 (29): 29963–73. doi:10.1074/jbc.M404452200. PMID 15123677.
• Caputi M, Freund M, Kammler S, et al. (2004). "A Bidirectional SF2/ASF- and SRp40-Dependent Splicing Enhancer Regulates Human Immunodeficiency Virus Type 1 rev, env, vpu, and nef Gene Expression". J. Virol. 78 (12): 6517–26. doi:10.1128/JVI.78.12.6517-6526.2004. PMC 416506. PMID 15163745.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.