SFRS6

Serine/arginine-rich splicing factor 6
Identifiers
Symbols	SRSF6 ; B52; HEL-S-91; SFRS6; SRP55
External IDs	OMIM: 601944 MGI: 1915246 HomoloGene: 110783 GeneCards: SRSF6 Gene
Gene ontology Molecular function • nucleotide binding • RNA binding • protein binding • pre-mRNA binding • poly(A) RNA binding Cellular component • nucleoplasm • nuclear speck Biological process • alternative mRNA splicing, via spliceosome • regulation of alternative mRNA splicing, via spliceosome • mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • mRNA splice site selection • mRNA export from nucleus • RNA splicing • gene expression • regulation of keratinocyte proliferation • mRNA 3'-end processing • negative regulation of keratinocyte differentiation • negative regulation of mRNA splicing, via spliceosome • positive regulation of epithelial cell proliferation involved in lung morphogenesis • negative regulation of cell death • regulation of wound healing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6431	67996
Ensembl	ENSG00000124193	ENSMUSG00000016921
UniProt	Q13247	Q3TWW8
RefSeq (mRNA)	NM_006275	NM_026499
RefSeq (protein)	NP_006266	NP_080775
Location (UCSC)	Chr 20: 43.46 – 43.46 Mb	Chr 2: 162.93 – 162.94 Mb
PubMed search

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.^[1][2]

The protein encoded by this gene is involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.^[2]

References

1. Screaton GR, Caceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR (Oct 1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". EMBO J 14 (17): 4336–49. PMC 394518. PMID 7556075.
2. "Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6".

Further reading

• Zahler AM, Lane WS, Stolk JA, Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
• Ramchatesingh J, Zahler AM, Neugebauer KM, et al. (1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Mol. Cell. Biol. 15 (9): 4898–907. PMC 230736. PMID 7651409.
• Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
• Nagel RJ, Lancaster AM, Zahler AM (1998). "Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55". RNA 4 (1): 11–23. PMC 1369592. PMID 9436904.
• Liu HX, Zhang M, Krainer AR (1998). "Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins". Genes Dev. 12 (13): 1998–2012. doi:10.1101/gad.12.13.1998. PMC 316967. PMID 9649504.
• Lemaire R, Winne A, Sarkissian M, Lafyatis R (1999). "SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation". Eur. J. Immunol. 29 (3): 823–37. doi:10.1002/(SICI)1521-4141(199903)29:03<823::AID-IMMU823>3.0.CO;2-C. PMID 10092085.
• Paillard F (1999). "A novel soluble chimera for the treatment of familial hypercholesterolemia". Hum. Gene Ther. 10 (7): 1093–4. doi:10.1089/10430349950018085. PMID 10340541.
• Barnard DC, Patton JG (2000). "Identification and Characterization of a Novel Serine-Arginine-Rich Splicing Regulatory Protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.
• Monsalve M, Wu Z, Adelmant G, et al. (2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Mol. Cell 6 (2): 307–16. doi:10.1016/S1097-2765(00)00031-9. PMID 10983978.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochim. Biophys. Acta 1625 (2): 141–52. doi:10.1016/S0167-4781(02)00600-0. PMID 12531473.
• Tran Q, Roesser JR (2003). "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing". Biochemistry 42 (4): 951–7. doi:10.1021/bi026753a. PMID 12549914.
• Lai MC, Lin RI, Tarn WY (2003). "Differential effects of hyperphosphorylation on splicing factor SRp55". Biochem. J. 371 (Pt 3): 937–45. doi:10.1042/BJ20021827. PMC 1223332. PMID 12549978.
• Pind MT, Watson PH (2004). "SR protein expression and CD44 splicing pattern in human breast tumours". Breast Cancer Res. Treat. 79 (1): 75–82. doi:10.1023/A:1023338718974. PMID 12779084.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.