SH2B3
| SH2B adaptor protein 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SH2B3 ; IDDM20; LNK | ||||||||||||
| External IDs | OMIM: 605093 MGI: 893598 HomoloGene: 36179 GeneCards: SH2B3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10019 | 16923 | |||||||||||
| Ensembl | ENSG00000111252 | ENSMUSG00000042594 | |||||||||||
| UniProt | Q9UQQ2 | O09039 | |||||||||||
| RefSeq (mRNA) | NM_001291424 | NM_001306126 | |||||||||||
| RefSeq (protein) | NP_001278353 | NP_001293055 | |||||||||||
| Location (UCSC) |
Chr 12: 111.41 – 111.45 Mb |
Chr 5: 121.82 – 121.84 Mb | |||||||||||
| PubMed search | |||||||||||||
SH2B adapter protein 3 is a protein that in humans is encoded by the SH2B3 gene.[1][2]
Function
T-cell activation requires stimulation of the T-cell receptor (TCR; see MIM 186880)-CD3 (see CD3Z; MIM 186780) complex, followed by recruitment of an array of intracellular signaling proteins (e.g., GRB2 (MIM 108355) and PLCG1 (MIM 172420)). Mediating the interaction between the extracellular receptors and intracellular signaling pathways are adaptor proteins such as LAT (MIM 602354), TRIM (MIM 604962), and LNK.[supplied by OMIM][2]
Interactions
SH2B3 has been shown to interact with Filamin.[3]
References
- ↑ Li Y, He X, Schembri-King J, Jakes S, Hayashi J (June 2000). "Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation". J Immunol 164 (10): 5199–206. doi:10.4049/jimmunol.164.10.5199. PMID 10799879.
- 1 2 "Entrez Gene: SH2B3 SH2B adaptor protein 3".
- ↑ He X, Li Y, Schembri-King J, Jakes S, Hayashi J (August 2000). "Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein". Mol. Immunol. 37 (10): 603–12. doi:10.1016/S0161-5890(00)00070-5. PMID 11163396.
Further reading
- Motto DG, Musci MA, Ross SE, Koretzky GA (1996). "Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells.". Mol. Cell. Biol. 16 (6): 2823–9. PMC 231274. PMID 8649391.
- Hendricks-Taylor LR, Motto DG, Zhang J, Siraganian RP, Koretzky GA (1997). "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.". J. Biol. Chem. 272 (2): 1363–7. doi:10.1074/jbc.272.2.1363. PMID 8995445.
- Takaki S, Watts JD, Forbush KA, Nguyen NT, Hayashi J, Alberola-Ila J, Aebersold R, Perlmutter RM (1997). "Characterization of Lnk. An adaptor protein expressed in lymphocytes.". J. Biol. Chem. 272 (23): 14562–70. doi:10.1074/jbc.272.23.14562. PMID 9169414.
- He X, Li Y, Schembri-King J, Jakes S, Hayashi J (2001). "Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein.". Mol. Immunol. 37 (10): 603–12. doi:10.1016/S0161-5890(00)00070-5. PMID 11163396.
- Takaki S, Morita H, Tezuka Y, Takatsu K (2002). "Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk.". J. Exp. Med. 195 (2): 151–60. doi:10.1084/jem.20011170. PMC 2193601. PMID 11805142.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Fitau J, Boulday G, Coulon F, Quillard T, Charreau B (2006). "The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways.". J. Biol. Chem. 281 (29): 20148–59. doi:10.1074/jbc.M510997200. PMID 16644735.
- Wan M, Li Y, Xue H, Li Q, Li J (2006). "TNF-alpha induces Lnk expression through PI3K-dependent signaling pathway in human umbilical vein endothelial cells.". J. Surg. Res. 136 (1): 53–7. doi:10.1016/j.jss.2006.07.004. PMID 17007883.
External links
- SH2B3 human gene location in the UCSC Genome Browser.
- SH2B3 human gene details in the UCSC Genome Browser.
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