SHC2

SHC (Src homology 2 domain containing) transforming protein 2
Identifiers
Symbols	SHC2 ; SCK; SHCB; SLI
External IDs	OMIM: 605217 MGI: 106180 HomoloGene: 19127 ChEMBL: 3299 GeneCards: SHC2 Gene
Gene ontology Molecular function • protein binding • protein kinase binding • receptor tyrosine kinase binding Cellular component • cellular_component • cytosol • plasma membrane Biological process • activation of MAPK activity • transmembrane receptor protein tyrosine kinase signaling pathway • Ras protein signal transduction • insulin receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25759	216148
Ensembl	ENSG00000129946	ENSMUSG00000020312
UniProt	P98077	Q8BMC3
RefSeq (mRNA)	NM_012435	NM_001024539
RefSeq (protein)	NP_036567	NP_001019710
Location (UCSC)	Chr 19: 0.42 – 0.46 Mb	Chr 10: 79.62 – 79.64 Mb
PubMed search

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.^[1][2][3]

Interactions

SHC2 has been shown to interact with Kinase insert domain receptor.^[4]

References

1. Kavanaugh WM, Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science 266 (5192): 1862–5. doi:10.1126/science.7527937. PMID 7527937.
2. Nakamura T, Muraoka S, Sanokawa R, Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
3. "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2".
4. Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. (England) 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680.

Further reading

• Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes.". Physiol. Genomics 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu HY, Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.". J. Biol. Chem. 277 (29): 26046–56. doi:10.1074/jbc.M111659200. PMID 12006576.
• Warner AJ, Lopez-Dee J, Knight EL, et al. (2001). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.". Biochem. J. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. PMC 1220983. PMID 10749680.
• Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.". Oncogene 13 (3): 633–41. PMID 8760305.