SHC3

SHC (Src homology 2 domain containing) transforming protein 3
Identifiers
Symbols	SHC3 ; N-Shc; NSHC; RAI; SHCC
External IDs	OMIM: 605263 MGI: 106179 HomoloGene: 7536 GeneCards: SHC3 Gene
Gene ontology Molecular function • signal transducer activity • protein binding • protein kinase binding • receptor tyrosine kinase binding Cellular component • cellular_component • cytosol • plasma membrane Biological process • transmembrane receptor protein tyrosine kinase signaling pathway • epidermal growth factor receptor signaling pathway • Ras protein signal transduction • central nervous system development • learning or memory • insulin receptor signaling pathway • synaptic transmission, glutamatergic • neurotrophin TRK receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53358	20418
Ensembl	ENSG00000148082	ENSMUSG00000021448
UniProt	Q92529	Q61120
RefSeq (mRNA)	NM_016848	NM_009167
RefSeq (protein)	NP_058544	NP_033193
Location (UCSC)	Chr 9: 89.01 – 89.18 Mb	Chr 13: 51.43 – 51.57 Mb
PubMed search

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.^[1][2]

Interactions

SHC3 has been shown to interact with RICS^[3] and TrkB.^[4][5]

References

1. Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N (November 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene 13 (6): 1111–21. PMID 8808684.
2. "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".
3. Nakamura, Takeshi; Komiya Misako; Sone Kiyoaki; Hirose Eiji; Gotoh Noriko; Morii Hiroshi; Ohta Yasutaka; Mori Nozomu (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. (United States) 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. ISSN 0270-7306. PMC 139861. PMID 12446789.
4. Nakamura, T; Muraoka S; Sanokawa R; Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. (UNITED STATES) 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. ISSN 0021-9258. PMID 9507002.
5. Suzuki, Shingo; Mizutani Masaharu; Suzuki Kenji; Yamada Masashi; Kojima Masami; Hatanaka Hiroshi; Koizumi Shinichi (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. (United States) 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. ISSN 0006-291X. PMID 12074588.

Further reading

• O'Bryan JP, Songyang Z, Cantley L, et al. (1996). "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.". Proc. Natl. Acad. Sci. U.S.A. 93 (7): 2729–34. doi:10.1073/pnas.93.7.2729. PMC 39699. PMID 8610109.
• Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.". Oncogene 13 (3): 633–41. PMID 8760305.
• Menegon A, Leoni C, Benfenati F, Valtorta F (1997). "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum.". Biochem. Biophys. Res. Commun. 238 (3): 800–5. doi:10.1006/bbrc.1997.7393. PMID 9325171.
• Wang JF, Ganju RK, Liu ZY, et al. (1997). "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor.". Blood 90 (9): 3507–15. PMID 9345034.
• Nakamura T, Muraoka S, Sanokawa R, Mori N (1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.". J. Biol. Chem. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
• Cook KK, Fadool DA (2002). "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase.". J. Biol. Chem. 277 (15): 13268–80. doi:10.1074/jbc.M108898200. PMC 2779217. PMID 11812778.
• Tarr PE, Roncarati R, Pelicci G, et al. (2002). "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.". J. Biol. Chem. 277 (19): 16798–804. doi:10.1074/jbc.M110286200. PMID 11877420.
• Liu HY, Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.". J. Biol. Chem. 277 (29): 26046–56. doi:10.1074/jbc.M111659200. PMID 12006576.
• Miyake I, Hakomori Y, Shinohara A, et al. (2002). "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines.". Oncogene 21 (38): 5823–34. doi:10.1038/sj.onc.1205735. PMID 12185581.
• Pelicci G, Troglio F, Bodini A, et al. (2002). "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.". Mol. Cell. Biol. 22 (20): 7351–63. doi:10.1128/MCB.22.20.7351-7363.2002. PMC 139827. PMID 12242309.
• Nakamura T, Komiya M, Sone K, et al. (2003). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.". Mol. Cell. Biol. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. PMC 139861. PMID 12446789.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Miyake I, Hakomori Y, Misu Y, et al. (2005). "Domain-specific function of ShcC docking protein in neuroblastoma cells.". Oncogene 24 (19): 3206–15. doi:10.1038/sj.onc.1208523. PMID 15735675.
• Magrassi L, Conti L, Lanterna A, et al. (2005). "Shc3 affects human high-grade astrocytomas survival.". Oncogene 24 (33): 5198–206. doi:10.1038/sj.onc.1208708. PMID 15870690.
• De Falco V, Guarino V, Malorni L, et al. (2005). "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors.". Oncogene 24 (41): 6303–13. doi:10.1038/sj.onc.1208776. PMID 15940252.
• Toschi E, Bacigalupo I, Strippoli R, et al. (2006). "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.". Mol. Biol. Cell 17 (4): 1985–94. doi:10.1091/mbc.E05-08-0717. PMC 1415297. PMID 16436505.
• Li MD, Sun D, Lou XY, et al. (2007). "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence.". Mol. Psychiatry 12 (5): 462–73. doi:10.1038/sj.mp.4001933. PMID 17179996.