SHOC2

SHOC2 leucine-rich repeat scaffold protein
Identifiers
Symbols	SHOC2 ; SIAA0862; SOC2; SUR8
External IDs	OMIM: 602775 MGI: 1927197 HomoloGene: 7219 GeneCards: SHOC2 Gene
Gene ontology Molecular function • protein phosphatase regulator activity • protein phosphatase binding Cellular component • protein phosphatase type 1 complex • nucleus • nucleoplasm • cytoplasm Biological process • Ras protein signal transduction • fibroblast growth factor receptor signaling pathway • positive regulation of Ras protein signal transduction • regulation of catalytic activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8036	56392
Ensembl	ENSG00000108061	ENSMUSG00000024976
UniProt	Q9UQ13	O88520
RefSeq (mRNA)	NM_001269039	NM_001168505
RefSeq (protein)	NP_001255968	NP_001161977
Location (UCSC)	Chr 10: 110.92 – 111.01 Mb	Chr 19: 53.94 – 54.03 Mb
PubMed search

Leucine-rich repeat protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene.^[1][2][3][4] Mutations that result in lipidation (specifically Myristoylation) of SHOC2 can cause Noonan syndrome.^[5]

Interactions

SHOC2 has been shown to interact with C-Raf^[3] and HRAS.^[3]

References

1. Selfors LM, Schutzman JL, Borland CZ, Stern MJ (Jul 1998). "soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6903–8. doi:10.1073/pnas.95.12.6903. PMC 22679. PMID 9618511.
2. Sieburth DS, Sun Q, Han M (Aug 1998). "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans". Cell 94 (1): 119–30. doi:10.1016/S0092-8674(00)81227-1. PMID 9674433.
3. Li W, Han M, Guan KL (May 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. PMC 316541. PMID 10783161.
4. "Entrez Gene: SHOC2 soc-2 suppressor of clear homolog (C. elegans)".
5. Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M (Sep 2009). "Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair". Nature Genetics 41 (9): 1022–6. doi:10.1038/ng.425. PMID 19684605.

Further reading

• Dai P, Xiong WC, Mei L (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex". J. Biol. Chem. 281 (2): 927–33. doi:10.1074/jbc.M507360200. PMID 16301319.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.