SIGIRR

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Identifiers
Symbols	SIGIRR ; TIR8
External IDs	OMIM: 605478 MGI: 1344402 HomoloGene: 36399 GeneCards: SIGIRR Gene
Gene ontology Molecular function • protein binding Cellular component • membrane • integral component of membrane Biological process • negative regulation of cytokine-mediated signaling pathway • acute-phase response • signal transduction • negative regulation of lipopolysaccharide-mediated signaling pathway • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of chemokine biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59307	24058
Ensembl	ENSG00000185187	ENSMUSG00000025494
UniProt	Q6IA17	Q9JLZ8
RefSeq (mRNA)	NM_001135053	NM_023059
RefSeq (protein)	NP_001128525	NP_075546
Location (UCSC)	Chr 11: 0.41 – 0.42 Mb	Chr 7: 141.09 – 141.1 Mb
PubMed search

Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.^[1][2]

It has been observed to modulate immune responses, colonic epithelial homeostasis and tumorigenesis.^[3][4]

Interactions

SIGIRR has been shown to interact with TRAF6.^[3]

References

1. Thomassen E, Renshaw BR, Sims JE (Jul 1999). "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily". Cytokine 11 (6): 389–99. doi:10.1006/cyto.1998.0452. PMID 10346978.
2. "Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain".
3. Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X (September 2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling". Nat. Immunol. 4 (9): 920–7. doi:10.1038/ni968. PMID 12925853.
4. Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X (April 2007). "The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis". Immunity 26 (4): 461–75. doi:10.1016/j.immuni.2007.02.012. PMID 17398123.

Further reading

• Du X, Poltorak A, Wei Y, Beutler B (2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution.". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Polentarutti N, Rol GP, Muzio M, et al. (2004). "Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.". Eur. Cytokine Netw. 14 (4): 211–8. PMID 14715412.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Qin J, Qian Y, Yao J, et al. (2005). "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms.". J. Biol. Chem. 280 (26): 25233–41. doi:10.1074/jbc.M501363200. PMID 15866876.