SIPA1L1

Signal-induced proliferation-associated 1 like 1
Identifiers
Symbols	SIPA1L1 ; E6TP1
External IDs	MGI: 2443679 HomoloGene: 9189 GeneCards: SIPA1L1 Gene
Gene ontology Molecular function • molecular_function • GTPase activator activity • ephrin receptor binding Cellular component • cellular_component • cytoplasm • cytoskeleton • postsynaptic density • cell junction • dendritic spine • postsynaptic membrane Biological process • biological_process • actin cytoskeleton reorganization • regulation of GTPase activity • ephrin receptor signaling pathway • regulation of synaptic plasticity • regulation of axonogenesis • regulation of small GTPase mediated signal transduction • regulation of dendritic spine morphogenesis • activation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26037	217692
Ensembl	ENSG00000197555	ENSMUSG00000042700
UniProt	O43166	Q8C0T5
RefSeq (mRNA)	NM_001284245	NM_001167983
RefSeq (protein)	NP_001271174	NP_001161455
Location (UCSC)	Chr 14: 71.32 – 71.74 Mb	Chr 12: 82.17 – 82.45 Mb
PubMed search

Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.^[1][2]

References

1. Gao Q, Srinivasan S, Boyer SN, Wazer DE, Band V (Feb 1999). "The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation". Mol Cell Biol 19 (1): 733–44. PMC 83930. PMID 9858596.
2. "Entrez Gene: SIPA1L1 signal-induced proliferation-associated 1 like 1".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lee C, Wooldridge TR, Laimins LA (2007). "Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle". Virology 358 (1): 201–10. doi:10.1016/j.virol.2006.08.028. PMID 16999984.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Chih DY, Park DJ, Gross M, et al. (2005). "Protein partners of C/EBPepsilon". Exp. Hematol. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Pak DT, Yang S, Rudolph-Correia S, et al. (2001). "Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP". Neuron 31 (2): 289–303. doi:10.1016/S0896-6273(01)00355-5. PMID 11502259.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.