SKAP2

Src kinase associated phosphoprotein 2
PDB rendering based on 1u5e.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3OMH​
Identifiers
Symbols	SKAP2 ; PRAP; RA70; SAPS; SCAP2; SKAP-HOM; SKAP55R
External IDs	OMIM: 605215 MGI: 1889206 HomoloGene: 2919 GeneCards: SKAP2 Gene
Gene ontology Molecular function • SH3/SH2 adaptor activity • protein binding Cellular component • nucleoplasm • cytoplasm • cytosol • plasma membrane Biological process • immune response-activating signal transduction • protein complex assembly • signal transduction • negative regulation of cell proliferation • positive regulation of signal transduction • B cell activation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8935	54353
Ensembl	ENSG00000005020	ENSMUSG00000059182
UniProt	O75563	Q3UND0
RefSeq (mRNA)	NM_001303468	NM_018773
RefSeq (protein)	NP_001290397	NP_061243
Location (UCSC)	Chr 7: 26.67 – 27 Mb	Chr 6: 51.86 – 52.01 Mb
PubMed search

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.^[1][2][3]

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.^[3]

References

1. Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (Jan 1999). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochem Biophys Res Commun 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776.
2. Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (Oct 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Lett 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858.
3. "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Liu J, Kang H, Raab M, et al. (1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779–84. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.
• Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
• Asazuma N, Wilde JI, Berlanga O, et al. (2000). "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin". J. Biol. Chem. 275 (43): 33427–34. doi:10.1074/jbc.M001439200. PMID 10942756.
• Curtis DJ, Jane SM, Hilton DJ, et al. (2001). "Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest". Exp. Hematol. 28 (11): 1250–9. doi:10.1016/S0301-472X(00)00537-3. PMID 11063873.
• Moog-Lutz C, Peterson EJ, Lutz PG, et al. (2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". J. Biol. Chem. 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322.
• Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Takahashi T, Yamashita H, Nagano Y, et al. (2004). "Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation". J. Biol. Chem. 278 (43): 42225–33. doi:10.1074/jbc.M213217200. PMID 12893833.
• Park SY, Avraham HK, Avraham S (2004). "RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner". J. Biol. Chem. 279 (32): 33315–22. doi:10.1074/jbc.M313527200. PMID 15166227.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.