SKIP

Inositol polyphosphate-5-phosphatase K
Identifiers
Symbols	INPP5K ; PPS; SKIP
External IDs	OMIM: 607875 MGI: 1194899 HomoloGene: 75059 GeneCards: INPP5K Gene
EC number	3.1.3.56
Gene ontology Molecular function • inositol-polyphosphate 5-phosphatase activity • vasopressin receptor activity • protein binding • inositol bisphosphate phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity • phosphatidylinositol trisphosphate phosphatase activity • phosphatidylinositol phosphate 5-phosphatase activity • lipid phosphatase activity • inositol trisphosphate phosphatase activity • inositol-1,4,5-trisphosphate 5-phosphatase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Cellular component • ruffle • nucleus • cytoplasm • endoplasmic reticulum • trans-Golgi network • cytosol • plasma membrane • membrane • ruffle membrane • neuron projection • perinuclear region of cytoplasm Biological process • in utero embryonic development • negative regulation of protein phosphorylation • regulation of glycogen biosynthetic process • negative regulation of protein kinase activity • protein dephosphorylation • phospholipid metabolic process • phosphatidylinositol biosynthetic process • G-protein coupled receptor signaling pathway • negative regulation of peptidyl-threonine phosphorylation • negative regulation of glucose transport • dephosphorylation • actin cytoskeleton organization • cellular response to insulin stimulus • cellular response to hormone stimulus • negative regulation of peptidyl-serine phosphorylation • negative regulation of dephosphorylation • positive regulation of urine volume • glucose homeostasis • negative regulation of MAP kinase activity • negative regulation by host of viral transcription • small molecule metabolic process • negative regulation of glycogen biosynthetic process • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • negative regulation of insulin receptor signaling pathway • inositol phosphate dephosphorylation • phosphatidylinositol dephosphorylation • negative regulation of stress fiber assembly • negative regulation of protein kinase B signaling • negative regulation of calcium ion transport • cellular response to cAMP • cellular response to tumor necrosis factor • cellular response to epidermal growth factor stimulus • protein targeting to plasma membrane • negative regulation of protein targeting to membrane • ruffle assembly • negative regulation of glycogen (starch) synthase activity • positive regulation of renal water transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51763	19062
Ensembl	ENSG00000132376	ENSMUSG00000006127
UniProt	Q9BT40	Q8C5L6
RefSeq (mRNA)	NM_001135642	NM_008916
RefSeq (protein)	NP_001129114	NP_032942
Location (UCSC)	Chr 17: 1.49 – 1.52 Mb	Chr 11: 75.63 – 75.65 Mb
PubMed search

SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.^[1]

Function

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[1] Overexpression of SKIP in mice affects osmoregulation in kidney collecting ducts.^[2]

References

1. "Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase".
2. Pernot E, Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M, Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C, Devuyst O, Schurmans S (Dec 2011). "The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system". Pflügers Archiv 462 (6): 871–83. doi:10.1007/s00424-011-1028-0. PMID 21938401.

Further reading

• Drayer AL, Pesesse X, De Smedt F, Communi D, Moreau C, Erneux C (Nov 1996). "The family of inositol and phosphatidylinositol polyphosphate 5-phosphatases". Biochemical Society Transactions 24 (4): 1001–5. doi:10.1042/bst0241001. PMID 8968500.
• Mitchell CA, Brown S, Campbell JK, Munday AD, Speed CJ (Nov 1996). "Regulation of second messengers by the inositol polyphosphate 5-phosphatases". Biochemical Society Transactions 24 (4): 994–1000. doi:10.1042/bst0240994. PMID 8968499.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y (Nov 2005). "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas". The International Journal of Biochemistry & Cell Biology 37 (11): 2273–83. doi:10.1016/j.biocel.2005.02.028. PMID 16002321.
• Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (Apr 2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". American Journal of Human Genetics 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
• Ijuin T, Takenawa T (Feb 2003). "SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation". Molecular and Cellular Biology 23 (4): 1209–20. doi:10.1128/MCB.23.4.1209-1220.2003. PMC 141139. PMID 12556481.
• Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD, Prescott M, Whisstock JC, Mitchell CA (Mar 2003). "Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation". The Journal of Biological Chemistry 278 (13): 11376–85. doi:10.1074/jbc.M209991200. PMID 12536145.
• Ijuin T, Mochizuki Y, Fukami K, Funaki M, Asano T, Takenawa T (Apr 2000). "Identification and characterization of a novel inositol polyphosphate 5-phosphatase". The Journal of Biological Chemistry 275 (15): 10870–5. doi:10.1074/jbc.275.15.10870. PMID 10753883.