SLA2

Src-like-adaptor 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4M4Z​
Identifiers
Symbols	SLA2 ; C20orf156; MARS; SLAP-2; SLAP2
External IDs	OMIM: 606577 HomoloGene: 49989 GeneCards: SLA2 Gene
Gene ontology Molecular function • SH3/SH2 adaptor activity • protein binding • protein N-terminus binding Cellular component • cytoplasm • late endosome • plasma membrane • endosome membrane • cytoplasmic membrane-bounded vesicle Biological process • negative regulation of transcription from RNA polymerase II promoter • positive regulation of signal transduction • B cell mediated immunity • intracellular receptor signaling pathway • T cell activation • regulation of immune response • negative regulation of calcium-mediated signaling • antigen receptor-mediated signaling pathway • negative regulation of B cell activation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84174	77799
Ensembl	ENSG00000101082	ENSMUSG00000027636
UniProt	Q9H6Q3	Q8R4L0
RefSeq (mRNA)	NM_032214	NM_029983
RefSeq (protein)	NP_115590	NP_084259
Location (UCSC)	Chr 20: 36.61 – 36.65 Mb	Chr 2: 156.87 – 156.89 Mb
PubMed search

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.^[1][2]

Function

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.^[2]

Interactions

SLA2 has been shown to interact with Cbl gene.^[3]

References

1. Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med 194 (9): 1263–76. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592.
2. "Entrez Gene: SLA2 Src-like-adaptor 2".
3. Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.

Further reading

• Loreto MP, McGlade CJ (2003). "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v.". Oncogene 22 (2): 266–73. doi:10.1038/sj.onc.1206114. PMID 12527895.
• Loreto MP, Berry DM, McGlade CJ (2002). "Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
• Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.