SLC25A24

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4N5X​
Identifiers
Symbols	SLC25A24 ; APC1; SCAMC-1
External IDs	OMIM: 608744 HomoloGene: 92693 IUPHAR: 1077 GeneCards: SLC25A24 Gene
Gene ontology Molecular function • ATP transmembrane transporter activity • calcium ion binding Cellular component • cytoplasm • mitochondrion • mitochondrial inner membrane • integral component of membrane Biological process • mitochondrial transport • regulation of cell death • ATP transport • cellular response to oxidative stress • transmembrane transport • cellular response to calcium ion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29957	229731
Ensembl	ENSG00000085491	ENSMUSG00000040322
UniProt	Q6NUK1	Q8BMD8
RefSeq (mRNA)	NM_013386	NM_172685
RefSeq (protein)	NP_037518	NP_766273
Location (UCSC)	Chr 1: 108.13 – 108.2 Mb	Chr 3: 109.12 – 109.17 Mb
PubMed search

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 is a protein that in humans is encoded by the SLC25A24 gene. ^[1]

Function

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].

References

1. "Entrez Gene: Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24". Retrieved 2014-08-05.

Further reading

• Fiermonte, G; De Leonardis, F; Todisco, S; Palmieri, L; Lasorsa, F. M.; Palmieri, F (2004). "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution". The Journal of Biological Chemistry 279 (29): 30722–30. doi:10.1074/jbc.M400445200. PMID 15123600.
• Del Arco, A; Satrústegui, J (2004). "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains". The Journal of Biological Chemistry 279 (23): 24701–13. doi:10.1074/jbc.M401417200. PMID 15054102.
• Traba, J; Del Arco, A; Duchen, M. R.; Szabadkai, G; Satrústegui, J (2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering". Cell death and differentiation 19 (4): 650–60. doi:10.1038/cdd.2011.139. PMC 3307981. PMID 22015608.
• Palmieri, F (2013). "The mitochondrial transporter family SLC25: Identification, properties and physiopathology". Molecular aspects of medicine 34 (2–3): 465–84. doi:10.1016/j.mam.2012.05.005. PMID 23266187.
• Jia, L; Young, M. F.; Powell, J; Yang, L; Ho, N. C.; Hotchkiss, R; Robey, P. G.; Francomano, C. A. (2002). "Gene expression profile of human bone marrow stromal cells: High-throughput expressed sequence tag sequencing analysis". Genomics 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.