SLC35C2

Solute carrier family 35 (GDP-fucose transporter), member C2
Identifiers
Symbols	SLC35C2 ; BA394O2.1; C20orf5; CGI-15; OVCOV1
External IDs	MGI: 2385166 HomoloGene: 6581 IUPHAR: 1148 GeneCards: SLC35C2 Gene
Gene ontology Molecular function • antiporter activity Cellular component • endoplasmic reticulum-Golgi intermediate compartment • Golgi apparatus • cis-Golgi network • integral component of membrane • endoplasmic reticulum-Golgi intermediate compartment membrane Biological process • negative regulation of gene expression • UDP-glucose transport • protein O-linked fucosylation • positive regulation of Notch signaling pathway • anion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51006	228875
Ensembl	ENSG00000080189	ENSMUSG00000017664
UniProt	Q9NQQ7	Q8VCX2
RefSeq (mRNA)	NM_001281457	NM_001252573
RefSeq (protein)	NP_001268386	NP_001239502
Location (UCSC)	Chr 20: 46.35 – 46.36 Mb	Chr 2: 165.28 – 165.29 Mb
PubMed search

Solute carrier family 35 member C2 is a protein that in humans is encoded by the SLC35C2 gene.^[1][2][3]

Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene.^[3]

References

1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
2. Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW (Sep 2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics 76 (1-3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
3. "Entrez Gene: SLC35C2 solute carrier family 35, member C2".

Further reading

• Lash GE, Postovit LM, Matthews NE, et al. (2002). "Oxygen as a regulator of cellular phenotypes in pregnancy and cancer.". Can. J. Physiol. Pharmacol. 80 (2): 103–9. doi:10.1139/y02-008. PMID 11934252.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pires Martins R, Leach RE, Krawetz SA (2001). "Whole-body gene expression by data mining.". Genomics 72 (1): 34–42. doi:10.1006/geno.2000.6437. PMID 11247664.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Leach R, Duniec-Dmuchowski Z, Tanaka T, et al. (2002). "Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1→q13.2 by fluorescent in situ hybridization.". Cytogenet. Cell Genet. 94 (3-4): 252–3. doi:10.1159/000048828. PMID 11856893.
• Leach RE, Duniec-Dmuchowski ZM, Pesole G, et al. (2003). "Identification, molecular characterization, and tissue expression of OVCOV1.". Mamm. Genome 13 (11): 619–24. doi:10.1007/s00335-002-2185-4. PMID 12461647.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.