SLC38A1

Solute carrier family 38, member 1
Identifiers
Symbols	SLC38A1 ; ATA1; NAT2; SAT1; SNAT1
External IDs	OMIM: 608490 MGI: 2145895 HomoloGene: 12745 GeneCards: SLC38A1 Gene
Gene ontology Molecular function • sodium:amino acid symporter activity • protein binding • amino acid transmembrane transporter activity • neutral amino acid transmembrane transporter activity Cellular component • plasma membrane • integral component of plasma membrane • integral component of membrane • extracellular exosome Biological process • neurotransmitter uptake • amino acid transmembrane transport • ion transport • sodium ion transport • amino acid transport • synaptic transmission • neutral amino acid transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81539	105727
Ensembl	ENSG00000111371	ENSMUSG00000023169
UniProt	Q9H2H9	Q8K2P7
RefSeq (mRNA)	NM_001077484	NM_001166456
RefSeq (protein)	NP_001070952	NP_001159928
Location (UCSC)	Chr 12: 46.18 – 46.27 Mb	Chr 15: 96.57 – 96.64 Mb
PubMed search

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.^[1][2]

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001).[supplied by OMIM]^[2]

References

1. Wang H, Huang W, Sugawara M, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Sep 2000). "Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta". Biochem Biophys Res Commun 273 (3): 1175–9. doi:10.1006/bbrc.2000.3061. PMID 10891391.
2. "Entrez Gene: SLC38A1 solute carrier family 38, member 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Gu S, Roderick HL, Camacho P, Jiang JX (2001). "Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport.". J. Biol. Chem. 276 (26): 24137–44. doi:10.1074/jbc.M009003200. PMID 11325958.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Melone M, Quagliano F, Barbaresi P, et al. (2004). "Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex.". Cereb. Cortex 14 (5): 562–74. doi:10.1093/cercor/bhh018. PMID 15054072.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kondoh N, Imazeki N, Arai M, et al. (2007). "Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues.". Int. J. Oncol. 31 (1): 81–7. doi:10.3892/ijo.31.1.81. PMID 17549407.