SLC6A6

Solute carrier family 6 (neurotransmitter transporter), member 6
Identifiers
Symbols	SLC6A6 ; TAUT
External IDs	OMIM: 186854 MGI: 98488 HomoloGene: 2291 ChEMBL: 5762 GeneCards: SLC6A6 Gene
Gene ontology Molecular function • neurotransmitter:sodium symporter activity • taurine:sodium symporter activity Cellular component • plasma membrane • integral component of plasma membrane • integral component of membrane Biological process • amino acid transmembrane transport • cellular amino acid metabolic process • transport • ion transport • neurotransmitter transport • amino acid transport • taurine transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6533	21366
Ensembl	ENSG00000131389	ENSMUSG00000030096
UniProt	P31641	O35316
RefSeq (mRNA)	NM_001134367	NM_009320
RefSeq (protein)	NP_001127839	NP_033346
Location (UCSC)	Chr 3: 14.4 – 14.49 Mb	Chr 6: 91.68 – 91.76 Mb
PubMed search

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.^[1][2][3]

References

1. Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V (Jul 1994). "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta". Biochem J 300 (3): 893–900. PMC 1138249. PMID 8010975.
2. Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL (Mar 1993). "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells". FEBS Lett 318 (2): 139–44. doi:10.1016/0014-5793(93)80008-I. PMID 8382624.
3. "Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6".

Further reading

• Uchida S, Kwon HM, Yamauchi A, et al. (1992). "Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(−)-dependent taurine transporter that is regulated by hypertonicity.". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8230–4. doi:10.1073/pnas.89.17.8230. PMC 49891. PMID 1518851.
• Miyamoto Y, Liou GI, Sprinkle TJ (1996). "Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium.". Curr. Eye Res. 15 (3): 345–9. doi:10.3109/02713689609007631. PMID 8654117.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Mochizuki T, Satsu H, Shimizu M (2002). "Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells.". FEBS Lett. 517 (1–3): 92–6. doi:10.1016/S0014-5793(02)02584-X. PMID 12062416.
• Han X, Patters AB, Chesney RW (2002). "Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells". J. Biol. Chem. 277 (42): 39266–73. doi:10.1074/jbc.M205939200. PMID 12163498.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Han X, Chesney RW (2003). "Regulation of taurine transporter gene (TauT) by WT1". FEBS Lett. 540 (1–3): 71–6. doi:10.1016/S0014-5793(03)00227-8. PMID 12681485.
• Roos S, Powell TL, Jansson T (2004). "Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation". Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (4): R886–93. doi:10.1152/ajpregu.00232.2004. PMID 15166008.
• Satsu H, Manabe M, Shimizu M (2004). "Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter". FEBS Lett. 569 (1–3): 123–8. doi:10.1016/j.febslet.2004.05.062. PMID 15225620.
• Mochizuki T, Satsu H, Nakano T, Shimizu M (2005). "Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells". BioFactors 21 (1–4): 141–4. doi:10.1002/biof.552210128. PMID 15630186.
• Mochizuki T, Satsu H, Shimizu M (2005). "Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells". FEBS Lett. 579 (14): 3069–74. doi:10.1016/j.febslet.2005.04.063. PMID 15907840.
• Nakashima E, Pop-Busui R, Towns R, et al. (2006). "Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase". Antioxid. Redox Signal. 7 (11–12): 1530–42. doi:10.1089/ars.2005.7.1530. PMID 16356117.
• Iruloh CG, D'Souza SW, Speake PF, et al. (2007). "Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity". Am. J. Physiol., Cell Physiol. 292 (1): C332–41. doi:10.1152/ajpcell.00634.2005. PMID 16956961.