SLC9B2
| Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SLC9B2 ; NHA2; NHE10; NHEDC2 | ||||||||||||
| External IDs | OMIM: 611789 HomoloGene: 45381 GeneCards: SLC9B2 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 133308 | 97086 | |||||||||||
| Ensembl | ENSG00000164038 | ENSMUSG00000037994 | |||||||||||
| UniProt | Q86UD5 | Q5BKR2 | |||||||||||
| RefSeq (mRNA) | NM_001300754 | NM_178877 | |||||||||||
| RefSeq (protein) | NP_001287683 | NP_849208 | |||||||||||
| Location (UCSC) |
Chr 4: 103.02 – 103.09 Mb |
Chr 3: 135.31 – 135.35 Mb | |||||||||||
| PubMed search | |||||||||||||
Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 is a protein that in humans is encoded by the SLC9B2 gene. [1]
Function
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008].
References
Further reading
- Kondapalli, K. C.; Kallay, L. M.; Muszelik, M; Rao, R (2012). "Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient". Journal of Biological Chemistry 287 (43): 36239–50. doi:10.1074/jbc.M112.403550. PMC 3476291. PMID 22948142.
- Ha, B. G.; Hong, J. M.; Park, J. Y.; Ha, M. H.; Kim, T. H.; Cho, J. Y.; Ryoo, H. M.; Choi, J. Y.; Shin, H. I.; Chun, S. Y.; Kim, S. Y.; Park, E. K. (2008). "Proteomic profile of osteoclast membrane proteins: Identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion". Proteomics 8 (13): 2625–39. doi:10.1002/pmic.200701192. PMID 18600791.
- Huang, X; Morse, L. R.; Xu, Y; Zahradka, J; Sychrová, H; Stashenko, P; Fan, F; Battaglino, R. A. (2010). "Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae". Biochimica et Biophysica Acta (BBA) - General Subjects 1800 (12): 1241–7. doi:10.1016/j.bbagen.2010.08.001. PMC 2967667. PMID 20713131.
- Fuster, D. G.; Zhang, J; Shi, M; Bobulescu, I. A.; Andersson, S; Moe, O. W. (2008). "Characterization of the sodium/hydrogen exchanger NHA2". Journal of the American Society of Nephrology 19 (8): 1547–56. doi:10.1681/ASN.2007111245. PMC 2488271. PMID 18508966.
- Xiang, M; Feng, M; Muend, S; Rao, R (2007). "A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension". Proceedings of the National Academy of Sciences 104 (47): 18677–81. doi:10.1073/pnas.0707120104. PMC 2141836. PMID 18000046.
- Kalsi, G.; Kuo, P. -H.; Aliev, F.; Alexander, J.; McMichael, O.; Patterson, D. G.; Walsh, D.; Zhao, Z.; Schuckit, M.; Nurnberger Jr, J.; Edenberg, H.; Kramer, J.; Hesselbrock, V.; Tischfield, C. A.; Vladimirov, D. M.; Prescott, K. S.; Dick, B. P.; Kendler, K. S.; Riley, B. P. (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Human Molecular Genetics 19 (12): 2497–2506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
- Battaglino, R. A.; Pham, L; Morse, L. R.; Vokes, M; Sharma, A; Odgren, P. R.; Yang, M; Sasaki, H; Stashenko, P (2008). "NHA-oc/NHA2: A mitochondrial cation-proton antiporter selectively expressed in osteoclasts". Bone 42 (1): 180–92. doi:10.1016/j.bone.2007.09.046. PMC 3593247. PMID 17988971.
- Schushan, M; Xiang, M; Bogomiakov, P; Padan, E; Rao, R; Ben-Tal, N (2010). "Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension". Journal of Molecular Biology 396 (5): 1181–96. doi:10.1016/j.jmb.2009.12.055. PMC 2824056. PMID 20053353.
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