SLIT3

Slit guidance ligand 3
Identifiers
Symbols	SLIT3 ; MEGF5; SLIL2; SLIT1; Slit-3; slit2
External IDs	OMIM: 603745 MGI: 1315202 HomoloGene: 2303 GeneCards: SLIT3 Gene
Gene ontology Molecular function • calcium ion binding • Roundabout binding Cellular component • extracellular space • mitochondrion Biological process • axon guidance • negative regulation of cell proliferation • organ morphogenesis • negative regulation of gene expression • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration • negative regulation of cell growth • cellular response to hormone stimulus • Roundabout signaling pathway • axon extension involved in axon guidance • negative chemotaxis • response to cortisol • apoptotic process involved in luteolysis • negative regulation of chemokine-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6586	20564
Ensembl	ENSG00000184347	ENSMUSG00000056427
UniProt	O75094	Q9WVB4
RefSeq (mRNA)	NM_001271946	NM_011412
RefSeq (protein)	NP_001258875	NP_035542
Location (UCSC)	Chr 5: 168.66 – 169.3 Mb	Chr 11: 35.12 – 35.71 Mb
PubMed search

Slit homolog 3 protein is a protein that in humans is encoded by the SLIT3 gene.^[1][2][3]

References

1. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
2. Itoh A, Miyabayashi T, Ohno M, Sakano S (Feb 1999). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Res Mol Brain Res 62 (2): 175–186. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.
3. "Entrez Gene: SLIT3 slit homolog 3 (Drosophila)".

Further reading

• Holmes GP, Negus K, Burridge L, et al. (1999). "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis". Mech. Dev. 79 (1–2): 57–72. doi:10.1016/S0925-4773(98)00174-9. PMID 10349621.
• Little MH, Wilkinson L, Brown DL, et al. (2001). "Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein". Am. J. Physiol., Cell Physiol. 281 (2): C486–95. PMID 11443047.
• Marillat V, Cases O, Nguyen-Ba-Charvet KT, et al. (2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain". J. Comp. Neurol. 442 (2): 130–155. doi:10.1002/cne.10068. PMID 11754167. replacement character in |last6= at position 3 (help)
• Little M, Rumballe B, Georgas K, et al. (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". Int. J. Dev. Biol. 46 (4): 385–91. PMID 12141424.
• Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–652. doi:10.1291/hypres.25.647. PMID 12358155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Shi Y, Zhao X, Yu L, et al. (2004). "Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population". Genome Res. 14 (7): 1345–1349. doi:10.1101/gr.1758204. PMC 442150. PMID 15231749.
• Hammond R, Vivancos V, Naeem A, et al. (2005). "Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain". Development 132 (20): 4483–4495. doi:10.1242/dev.02038. PMID 16162649.
• Lin L, Isacson O (2006). "Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits". Stem Cells 24 (11): 2504–2513. doi:10.1634/stemcells.2006-0119. PMC 2613222. PMID 16840550.