SLK (gene)

STE20-like kinase
PDB rendering based on 2j51.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2J51​, 2JFL​, 2JFM​, 2UV2​
Identifiers
Symbols	SLK ; LOSK; STK2; bA16H23.1; se20-9
External IDs	MGI: 103241 HomoloGene: 22515 ChEMBL: 4202 GeneCards: SLK Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • ATP binding • identical protein binding • protein homodimerization activity Cellular component • cytoplasm • extracellular exosome Biological process • apoptotic process • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process • protein autophosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9748	20874
Ensembl	ENSG00000065613	ENSMUSG00000025060
UniProt	Q9H2G2	O54988
RefSeq (mRNA)	NM_001304743	NM_001164639
RefSeq (protein)	NP_001291672	NP_001158111
Location (UCSC)	Chr 10: 103.97 – 104.03 Mb	Chr 19: 47.58 – 47.65 Mb
PubMed search

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.^[1][2]

Interactions

SLK (gene) has been shown to interact with PDZK1.^[3]

References

1. Celenza JL, Carlson M (Sep 1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase". Science 233 (4769): 1175–80. doi:10.1126/science.3526554. PMID 3526554.
2. "Entrez Gene: SLK STE20-like kinase (yeast)".
3. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

Further reading

• Yan Y, Nguyen H, Dalmasso G, Sitaraman SV, Merlin D (Feb 2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform". Biochimica Et Biophysica Acta 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMC 1865517. PMID 17321610.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Chaar Z, O'reilly P, Gelman I, Sabourin LA (Sep 2006). "v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II". The Journal of Biological Chemistry 281 (38): 28193–9. doi:10.1074/jbc.M605665200. PMID 16837460.
• Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
• Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Dan I, Watanabe NM, Kusumi A (May 2001). "The Ste20 group kinases as regulators of MAP kinase cascades". Trends in Cell Biology 11 (5): 220–30. doi:10.1016/S0962-8924(01)01980-8. PMID 11316611.
• Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D (Jan 2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proceedings of the National Academy of Sciences of the United States of America 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
• Yamada E, Tsujikawa K, Itoh S, Kameda Y, Kohama Y, Yamamoto H (Feb 2000). "Molecular cloning and characterization of a novel human STE20-like kinase, hSLK". Biochimica Et Biophysica Acta 1495 (3): 250–62. doi:10.1016/S0167-4889(99)00164-0. PMID 10699464.
• Sabourin LA, Tamai K, Seale P, Wagner J, Rudnicki MA (Jan 2000). "Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region". Molecular and Cellular Biology 20 (2): 684–96. doi:10.1128/MCB.20.2.684-696.2000. PMC 85169. PMID 10611247.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.