SMARCC2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Identifiers
Symbols SMARCC2 ; BAF170; CRACC2; Rsc8
External IDs OMIM: 601734 MGI: 1915344 HomoloGene: 2312 GeneCards: SMARCC2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6601 68094
Ensembl ENSG00000139613 ENSMUSG00000025369
UniProt Q8TAQ2 Q6PDG5
RefSeq (mRNA) NM_001130420 NM_001114096
RefSeq (protein) NP_001123892 NP_001107568
Location (UCSC) Chr 12:
56.16 – 56.19 Mb
Chr 10:
128.46 – 128.49 Mb
PubMed search

SWI/SNF complex subunit SMARCC2 is a protein that in humans is encoded by the SMARCC2 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

SMARCC2 has been shown to interact with BAZ1B[4] and SMARCA4.[5][6][7]

References

  1. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (November 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
  2. Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (September 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
  3. 1 2 "Entrez Gene: SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2".
  4. Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (June 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
  5. Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMC 452280. PMID 8895581.
  6. Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM (November 2001). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex". Hum. Mol. Genet. (England) 10 (23): 2651–60. doi:10.1093/hmg/10.23.2651. ISSN 0964-6906. PMID 11726552.
  7. Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (November 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. PMID 9845365.

Further reading

External links


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