SMARCD3

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Identifiers
Symbols	SMARCD3 ; BAF60C; CRACD3; Rsc6p
External IDs	OMIM: 601737 MGI: 1914243 HomoloGene: 2314 GeneCards: SMARCD3 Gene
Gene ontology Molecular function • chromatin binding • transcription coactivator activity • receptor binding • protein binding • transcription factor binding • ligand-dependent nuclear receptor binding • ligand-dependent nuclear receptor transcription coactivator activity • nuclear hormone receptor binding Cellular component • nuclear chromatin • nucleus • nucleoplasm • cytoplasm • SWI/SNF complex • npBAF complex • nBAF complex Biological process • positive regulation of neuroblast proliferation • secondary heart field specification • cardiac right ventricle formation • neural retina development • nucleosome disassembly • chromatin remodeling • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • positive regulation of G2/M transition of mitotic cell cycle • muscle cell differentiation • regulation of protein binding • cellular lipid metabolic process • small molecule metabolic process • positive regulation of transcription, DNA-templated • positive regulation of smooth muscle cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6604	66993
Ensembl	ENSG00000082014	ENSMUSG00000028949
UniProt	Q6STE5	Q6P9Z1
RefSeq (mRNA)	NM_001003801	NM_025891
RefSeq (protein)	NP_001003801	NP_080167
Location (UCSC)	Chr 7: 151.24 – 151.28 Mb	Chr 5: 24.59 – 24.62 Mb
PubMed search

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a protein that in humans is encoded by the SMARCD3 gene.^[1][2][3]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene.^[3] Mutually exclusive incorporation of the variants into the larger SWI/SNF complex are thought to direct the complex to remodel particular sites in chromatin, leading to alterations in gene activity that dictate cell behavior or differentiation during development and disease.^[4]

References

1. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev 10 (17): 2117–2130. doi:10.1101/gad.10.17.2117. PMID 8804307.
2. Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics 51 (1): 140–143. doi:10.1006/geno.1998.5343. PMID 9693044.
3. "Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3".
4. Puri, P. L.; Mercola, M (2012). "BAF60 A, B, and Cs of muscle determination and renewal". Genes & Development 26 (24): 2673–83. doi:10.1101/gad.207415.112. PMC 3533072. PMID 23222103.

Further reading

• Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMC 452280. PMID 8895581.
• Shanahan F, Seghezzi W, Parry D, et al. (1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. 19 (2): 1460–9. PMC 116074. PMID 9891079.
• Barker N, Hurlstone A, Musisi H, et al. (2001). "The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation". EMBO J. 20 (17): 4935–4943. doi:10.1093/emboj/20.17.4935. PMC 125268. PMID 11532957.
• Otsuki T, Furukawa Y, Ikeda K, et al. (2002). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex". Hum. Mol. Genet. 10 (23): 2651–2660. doi:10.1093/hmg/10.23.2651. PMID 11726552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–164. doi:10.1038/nature01782. PMID 12853948.
• Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–665. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
• Debril MB, Gelman L, Fayard E, et al. (2004). "Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit". J. Biol. Chem. 279 (16): 16677–16686. doi:10.1074/jbc.M312288200. PMID 14701856.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mahmoudi T, Parra M, Vries RG, et al. (2006). "The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter". J. Biol. Chem. 281 (29): 19960–19968. doi:10.1074/jbc.M603336200. PMID 16687403.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.