SMPD2

Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Identifiers
Symbols	SMPD2 ; ISC1; NSMASE; NSMASE1
External IDs	OMIM: 603498 MGI: 1278330 HomoloGene: 31129 ChEMBL: 4712 GeneCards: SMPD2 Gene
EC number	3.1.4.12
Gene ontology Molecular function • sphingomyelin phosphodiesterase activity • metal ion binding Cellular component • intracellular • plasma membrane • integral component of plasma membrane • caveola Biological process • sphingolipid metabolic process • sphingomyelin metabolic process • glycosphingolipid metabolic process • response to mechanical stimulus • intracellular signal transduction • small molecule metabolic process • ceramide biosynthetic process • neurotrophin TRK receptor signaling pathway • apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6610	20598
Ensembl	ENSG00000135587	ENSMUSG00000019822
UniProt	O60906	O70572
RefSeq (mRNA)	NM_003080	NM_009213
RefSeq (protein)	NP_003071	NP_033239
Location (UCSC)	Chr 6: 109.44 – 109.44 Mb	Chr 10: 41.49 – 41.49 Mb
PubMed search

Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene.^[1][2]

References

1. Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W (May 1998). "Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?". Proc Natl Acad Sci U S A 95 (7): 3638–3643. doi:10.1073/pnas.95.7.3638. PMC 19888. PMID 9520418.
2. "Entrez Gene: SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Sawai H, Domae N, Nagan N, Hannun YA (2000). "Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C". J. Biol. Chem. 274 (53): 38131–38139. doi:10.1074/jbc.274.53.38131. PMID 10608884.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Marchesini N, Osta W, Bielawski J, et al. (2004). "Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells". J. Biol. Chem. 279 (24): 25101–25111. doi:10.1074/jbc.M313662200. PMID 15051724.
• Jensen JM, Fölster-Holst R, Baranowsky A, et al. (2004). "Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis". J. Invest. Dermatol. 122 (6): 1423–1431. doi:10.1111/j.0022-202X.2004.22621.x. PMID 15175033.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jana A, Pahan K (2005). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". J. Neurosci. 24 (43): 9531–9540. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476. PMID 15509740.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kim HT, Lee JY, Han BG, et al. (2007). "Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans". J. Dermatol. Sci. 46 (2): 143–146. doi:10.1016/j.jdermsci.2006.12.001. PMID 17212982.
• Tani M, Hannun YA (2007). "Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization". J. Biol. Chem. 282 (13): 10047–10056. doi:10.1074/jbc.M611249200. PMID 17272284.