SMPD3

Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Identifiers
Symbols	SMPD3 ; NSMASE2
External IDs	OMIM: 605777 MGI: 1927578 HomoloGene: 10260 IUPHAR: 2516 GeneCards: SMPD3 Gene
EC number	3.1.4.12
Gene ontology Molecular function • sphingomyelin phosphodiesterase activity • metal ion binding Cellular component • Golgi cis cisterna • Golgi membrane • plasma membrane Biological process • hematopoietic progenitor cell differentiation • sphingolipid metabolic process • sphingomyelin catabolic process • glycosphingolipid metabolic process • cell cycle • peptide hormone secretion • small molecule metabolic process • positive regulation of exosomal secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55512	58994
Ensembl	ENSG00000103056	ENSMUSG00000031906
UniProt	Q9NY59	Q9JJY3
RefSeq (mRNA)	NM_018667	NM_021491
RefSeq (protein)	NP_061137	NP_067466
Location (UCSC)	Chr 16: 68.36 – 68.45 Mb	Chr 8: 106.25 – 106.34 Mb
PubMed search

Sphingomyelin phosphodiesterase 3 is an enzyme that in humans is encoded by the SMPD3 gene.^[1][2]

References

1. Hofmann K, Tomiuk S, Wolff G, Stoffel W (Jun 2000). "Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase". Proc Natl Acad Sci U S A 97 (11): 5895–900. doi:10.1073/pnas.97.11.5895. PMC 18530. PMID 10823942.
2. "Entrez Gene: SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)".

Further reading

• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Marchesini N, Luberto C, Hannun YA (2003). "Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.". J. Biol. Chem. 278 (16): 13775–83. doi:10.1074/jbc.M212262200. PMID 12566438.
• Miura Y, Gotoh E, Nara F, et al. (2004). "Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.". FEBS Lett. 557 (1–3): 288–92. doi:10.1016/S0014-5793(03)01523-0. PMID 14741383.
• Marchesini N, Osta W, Bielawski J, et al. (2004). "Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells". J. Biol. Chem. 279 (24): 25101–11. doi:10.1074/jbc.M313662200. PMID 15051724.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jana A, Pahan K (2005). "Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase". J. Neurosci. 24 (43): 9531–40. doi:10.1523/JNEUROSCI.3085-04.2004. PMC 1955476. PMID 15509740.
• Krut O, Wiegmann K, Kashkar H, et al. (2006). "Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein". J. Biol. Chem. 281 (19): 13784–93. doi:10.1074/jbc.M511306200. PMID 16517606.
• Levy M, Castillo SS, Goldkorn T (2006). "nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis". Biochem. Biophys. Res. Commun. 344 (3): 900–5. doi:10.1016/j.bbrc.2006.04.013. PMID 16631623.
• Clarke CJ, Truong TG, Hannun YA (2007). "Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2". J. Biol. Chem. 282 (2): 1384–96. doi:10.1074/jbc.M609216200. PMID 17085432.
• Tani M, Hannun YA (2007). "Analysis of membrane topology of neutral sphingomyelinase 2". FEBS Lett. 581 (7): 1323–8. doi:10.1016/j.febslet.2007.02.046. PMC 1868537. PMID 17349629.
• Filosto S, Fry W, Knowlton A, Goldkorn T (2010). "Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)". JBC. 285 (14): 10213–22. doi:10.1074/jbc.M109.069963. PMC 2856226. PMID 20106976.