SMTN

Smoothelin
PDB rendering based on 2d87.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D87​
Identifiers
Symbols	SMTN ; FLJ35168; FLJ35365; FLJ35620; FLJ38597
External IDs	OMIM: 602127 MGI: 1354727 HomoloGene: 8482 GeneCards: SMTN Gene
Gene ontology Molecular function • actin binding • structural constituent of muscle Cellular component • nucleoplasm • cytoplasm • cytoskeleton • actin cytoskeleton Biological process • smooth muscle contraction • muscle organ development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6525	29856
Ensembl	ENSG00000183963	ENSMUSG00000020439
UniProt	P53814	Q921U8
RefSeq (mRNA)	NM_001207017	NM_001159284
RefSeq (protein)	NP_001193946	NP_001152756
Location (UCSC)	Chr 22: 31.06 – 31.1 Mb	Chr 11: 3.52 – 3.54 Mb
PubMed search

Smoothelin is a protein that in humans is encoded by the SMTN gene.^[1][2][3]

This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.^[3]

References

1. Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ (Sep 1997). "Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics 43 (2): 245–7. doi:10.1006/geno.1997.9999. PMID 9244445.
2. van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ (Sep 1996). "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells". J Cell Biol 134 (2): 401–11. doi:10.1083/jcb.134.2.401. PMC 2120883. PMID 8707825.
3. "Entrez Gene: SMTN smoothelin".

Further reading

• Luft FC (1999). "Differentiating one smooth operator from another.". J. Mol. Med. 77 (2): 255–7. doi:10.1007/s001090050347. PMID 10023778.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• van Eys GJ, Völler MC, Timmer ED, et al. (1997). "Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant.". Cell Struct. Funct. 22 (1): 65–72. doi:10.1247/csf.22.65. PMID 9113392.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Krämer J, Aguirre-Arteta AM, Thiel C, et al. (1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin.". J. Mol. Med. 77 (2): 294–8. doi:10.1007/s001090050352. PMID 10023782.
• Johansson B, Eriksson A, Ramaekers F, Thornell L (2000). "Smoothelin in adult and developing human arteries and myocardium.". Histochem. Cell Biol. 112 (4): 291–9. doi:10.1007/s004180050450. PMID 10550614.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Gsell S, Eschenhagen T, Kaspareit G, et al. (2000). "Apparent up-regulation of stimulatory G-protein alpha subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression.". FASEB J. 14 (1): 17–26. PMID 10627276.
• Krämer J, Quensel C, Meding J, et al. (2001). "Identification and characterization of novel smoothelin isoforms in vascular smooth muscle.". J. Vasc. Res. 38 (2): 120–32. doi:10.1159/000051039. PMID 11316948.
• Rensen SS, Thijssen VL, De Vries CJ, et al. (2002). "Expression of the smoothelin gene is mediated by alternative promoters.". Cardiovasc. Res. 55 (4): 850–63. doi:10.1016/S0008-6363(02)00491-1. PMID 12176134.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.