SNIP1

Smad nuclear interacting protein 1
Identifiers
Symbols	SNIP1 ; PMRED
External IDs	OMIM: 608241 MGI: 2156003 HomoloGene: 110886 GeneCards: SNIP1 Gene
Gene ontology Molecular function • protein binding • poly(A) RNA binding Cellular component • nucleoplasm • cytoplasm Biological process • regulation of transcription, DNA-templated • I-kappaB kinase/NF-kappaB signaling • production of miRNAs involved in gene silencing by miRNA • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79753	76793
Ensembl	ENSG00000163877	ENSMUSG00000050213
UniProt	Q8TAD8	Q8BIZ6
RefSeq (mRNA)	NM_024700	NM_175246
RefSeq (protein)	NP_078976	NP_780455
Location (UCSC)	Chr 1: 37.53 – 37.55 Mb	Chr 4: 125.07 – 125.07 Mb
PubMed search

Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene.^[1][2][3]

Interactions

SNIP1 has been shown to interact with EP300.^[1]

References

1. Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB (2000). "A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction". Genes Dev. 14 (13): 1605–16. doi:10.1101/gad.14.13.1605. PMC 316742. PMID 10887155.
2. Roche KC, Wiechens N, Owen-Hughes T, Perkins ND (2004). "The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression". Oncogene 23 (50): 8185–8195. doi:10.1038/sj.onc.1208025. PMID 15378006.
3. "Entrez Gene: SNIP1 Smad nuclear interacting protein 1".

Further reading

• Kim RH, Flanders KC, Birkey Reffey S, Anderson LA, Duckett CS, Perkins ND, Roberts AB (2001). "SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators". J. Biol. Chem. 276 (49): 46297–46304. doi:10.1074/jbc.M103819200. PMID 11567019.
• Lin Y, Martin J, Gruendler C, Farley J, Meng X, Li BY, Lechleider R, Huff C, Kim RH, Grasser WA, Paralkar V, Wang T (2002). "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)". BMC Cell Biol. 3: 15. doi:10.1186/1471-2121-3-15. PMC 117437. PMID 12097147.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene 24 (24): 3864–3874. doi:10.1038/sj.onc.1208556. PMID 15750622.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga S, Jen J, Perkins ND, Lechleider RJ, Roberts AB (2006). "SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes". Mol. Cell 24 (5): 771–783. doi:10.1016/j.molcel.2006.11.006. PMID 17157259.