SOAT2

Not to be confused with Acetyl-Coenzyme A acetyltransferase.
Sterol O-acyltransferase 2
Identifiers
Symbols SOAT2 ; ACACT2; ACAT2; ARGP2
External IDs OMIM: 601311 MGI: 1332226 HomoloGene: 68355 ChEMBL: 4465 GeneCards: SOAT2 Gene
EC number 2.3.1.26
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8435 223920
Ensembl ENSG00000167780 ENSMUSG00000023045
UniProt O75908 O88908
RefSeq (mRNA) NM_003578 NM_146064
RefSeq (protein) NP_003569 NP_666176
Location (UCSC) Chr 12:
53.1 – 53.12 Mb
Chr 15:
102.15 – 102.16 Mb
PubMed search

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.[1]

Function

This gene is a member of a small family of Acyl-CoA:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very-low-density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[1]

References

Further reading


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