SORBS3

Sorbin and SH3 domain containing 3
PDB rendering based on 2ct3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CT3​, 2DLM​, 2NWM​, 2YUP​
Identifiers
Symbols	SORBS3 ; SCAM-1; SCAM1; SH3D4
External IDs	OMIM: 610795 MGI: 700013 HomoloGene: 4218 GeneCards: SORBS3 Gene
Gene ontology Molecular function • structural constituent of cytoskeleton • protein binding • transcription factor binding • vinculin binding Cellular component • nucleus • cytosol • cytoskeleton • focal adhesion Biological process • negative regulation of transcription from RNA polymerase II promoter • muscle contraction • actin filament organization • cell adhesion • cell-substrate adhesion • positive regulation of MAPK cascade • positive regulation of cytoskeleton organization • positive regulation of stress fiber assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10174	20410
Ensembl	ENSG00000120896	ENSMUSG00000022091
UniProt	O60504	Q9R1Z8
RefSeq (mRNA)	NM_001018003	NM_001271407
RefSeq (protein)	NP_001018003	NP_001258336
Location (UCSC)	Chr 8: 22.54 – 22.58 Mb	Chr 14: 70.18 – 70.21 Mb
PubMed search

Vinexin is a protein that in humans is encoded by the SORBS3 gene.^[1][2][3]

Interactions

SORBS3 has been shown to interact with DLG5^[4] and MAPK1.^[5]

References

1. Kioka N, Sakata S, Kawauchi T, Amachi T, Akiyama SK, Okazaki K, Yaen C, Yamada KM, Aota S (Mar 1999). "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization". J Cell Biol 144 (1): 59–69. doi:10.1083/jcb.144.1.59. PMC 2148117. PMID 9885244.
2. Kioka N (Jan 2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku 74 (11): 1356–60. PMID 12510380.
3. "Entrez Gene: SORBS3 sorbin and SH3 domain containing 3".
4. Wakabayashi, Makoto; Ito Takuya; Mitsushima Masaru; Aizawa Sanae; Ueda Kazumitsu; Amachi Teruo; Kioka Noriyuki (Jun 2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. (United States) 278 (24): 21709–14. doi:10.1074/jbc.M211004200. ISSN 0021-9258. PMID 12657639.
5. Mitsushima, Masaru; Suwa Akira; Amachi Teruo; Ueda Kazumitsu; Kioka Noriyuki (Aug 2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. (United States) 279 (33): 34570–7. doi:10.1074/jbc.M402304200. ISSN 0021-9258. PMID 15184391.

Further reading

• Akamatsu M, Aota S, Suwa A, et al. (2000). "Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities.". J. Biol. Chem. 274 (50): 35933–7. doi:10.1074/jbc.274.50.35933. PMID 10585480.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wakabayashi M, Ito T, Mitsushima M, et al. (2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact.". J. Biol. Chem. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. PMID 12657639.
• Townson SM, Dobrzycka KM, Lee AV, et al. (2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor.". J. Biol. Chem. 278 (22): 20059–68. doi:10.1074/jbc.M212988200. PMID 12660241.
• Mitsushima M, Suwa A, Amachi T, et al. (2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin.". J. Biol. Chem. 279 (33): 34570–7. doi:10.1074/jbc.M402304200. PMID 15184391.
• Martens N, Wery M, Wang P, et al. (2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin.". Exp. Cell Res. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID 15242778.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bour G, Plassat JL, Bauer A, et al. (2005). "Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription.". J. Biol. Chem. 280 (17): 17027–37. doi:10.1074/jbc.M501344200. PMID 15734736.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mitsushima M, Ueda K, Kioka N (2006). "Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface.". Genes Cells 11 (9): 971–82. doi:10.1111/j.1365-2443.2006.00995.x. PMID 16923119.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Mizutani K, Ito H, Iwamoto I, et al. (2007). "Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth.". Oncogene 26 (50): 7122–31. doi:10.1038/sj.onc.1210512. PMID 17486060.

External links

• SORBS3 human gene location in the UCSC Genome Browser.
• SORBS3 human gene details in the UCSC Genome Browser.