SPDYA

Speedy/RINGO cell cycle regulator family member A
Identifiers
Symbols	SPDYA ; RINGO3; RINGOA; SPDY1; SPY1
External IDs	OMIM: 614029 MGI: 1918141 HomoloGene: 16357 GeneCards: SPDYA Gene
Gene ontology Molecular function • protein kinase binding Cellular component • nucleus Biological process • G1/S transition of mitotic cell cycle • cellular response to DNA damage stimulus • male meiosis • multicellular organismal development • positive regulation of cell proliferation • positive regulation of cyclin-dependent protein serine/threonine kinase activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	245711	70891
Ensembl	ENSG00000163806	ENSMUSG00000052525
UniProt	Q5MJ70	Q5IBH7
RefSeq (mRNA)	NM_001008779	NM_001142631
RefSeq (protein)	NP_001008779	NP_001136103
Location (UCSC)	Chr 2: 28.78 – 28.85 Mb	Chr 17: 71.55 – 71.59 Mb
PubMed search

Speedy protein A is a protein that in humans is encoded by the SPDYA gene.^[1][2][3][4]

Interactions

SPDYA has been shown to interact with CDKN1B.^[5]

References

1. Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ (Apr 2002). "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2". The Journal of Cell Biology 157 (3): 357–66. doi:10.1083/jcb.200109045. PMC 2173287. PMID 11980914.
2. Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ (Jul 2003). "Human Spy1 promotes survival of mammalian cells following DNA damage". Cancer Research 63 (13): 3701–7. PMID 12839962.
3. Cheng A, Xiong W, Ferrell JE, Solomon MJ (Jan 2005). "Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins". Cell Cycle 4 (1): 155–65. doi:10.4161/cc.4.1.1347. PMID 15611625.
4. "Entrez Gene: SPDYA speedy homolog A (Drosophila)".
5. Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.

Further reading

• Porter LA, Kong-Beltran M, Donoghue DJ (Sep 2003). "Spy1 interacts with p27Kip1 to allow G1/S progression". Molecular Biology of the Cell 14 (9): 3664–74. doi:10.1091/mbc.E02-12-0820. PMC 196558. PMID 12972555.
• Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ (Nov 2006). "Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation". The Journal of Biological Chemistry 281 (46): 35425–35. doi:10.1074/jbc.M604720200. PMID 16951407.
• McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ (Aug 2007). "Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27". Cell Cycle 6 (15): 1937–45. doi:10.4161/cc.6.15.4520. PMID 17671428.