SPINK6

Serine protease inhibitor Kazal-type 6 (SPINK6) is a protein encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14.[1] SPINK6 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK9.[2]

See also

References

  1. ↑ Meyer-Hoffert U, Wu Z, Kantyka T, Fischer J, Latendorf T, Hansmann B, Bartels J, He Y, Gläser R, Schröder JM. (October 2010). "Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases.". J Biol Chem. 285 (42): 32174–81. doi:10.1074/jbc.M109.091850. PMC 2952218. PMID 20667819.
  2. ↑ Furio L, Hovnanian A. (November 2011). "When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition.". J Invest Dermatol. 131 (11): 2169–73. doi:10.1038/jid.2011.295. PMID 21997416.


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