SPK
SPK may refer to:
- SPK (band), an Australian industrial music group
- Simultaneous pancreas-kidney transplant, see also Pancreas transplantation#Types
- Socialist Patients' Collective (German: Sozialistisches Patientenkollektiv)
- Strategic Plan Campine (Dutch: Strategisch Plan Kempen)
- Sutton Parkway railway station's station code
- Spkilla or SPK, stage name of Edwin Almonte
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