SPOCK1

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
Identifiers
Symbols	SPOCK1 ; SPOCK; TESTICAN; TIC1
External IDs	OMIM: 602264 MGI: 105371 HomoloGene: 80193 GeneCards: SPOCK1 Gene
Gene ontology Molecular function • serine-type endopeptidase inhibitor activity • cysteine-type endopeptidase inhibitor activity • calcium ion binding • metalloendopeptidase inhibitor activity Cellular component • proteinaceous extracellular matrix • extracellular space • cytoplasm • postsynaptic density • sarcoplasm • neuromuscular junction • node of Ranvier Biological process • regulation of cell growth • neuron migration • cell adhesion • signal transduction • nervous system development • negative regulation of cell-substrate adhesion • negative regulation of endopeptidase activity • negative regulation of neuron projection development • central nervous system neuron differentiation • neurogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6695	20745
Ensembl	ENSG00000152377	ENSMUSG00000056222
UniProt	Q08629	Q62288
RefSeq (mRNA)	NM_004598	NM_001166463
RefSeq (protein)	NP_004589	NP_001159935
Location (UCSC)	Chr 5: 136.98 – 137.6 Mb	Chr 13: 57.42 – 57.91 Mb
PubMed search

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.^[1][2]

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.^[2]

References

1. Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). "Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31". Genomics 48 (3): 377–80. doi:10.1006/geno.1997.5199. PMID 9545645.
2. "Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1".

Further reading

• Périn JP, Alliel PM, Jollès P, Bonnet F (1994). "Proteoglycans in male reproductive tract.". EXS 70: 191–7. doi:10.1007/978-3-0348-7545-5_11. PMID 7507743.
• Charbonnier F, Périn JP, Roussel G, et al. (1997). "[Cloning of testican/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology]". C. R. Seances Soc. Biol. Fil. 191 (1): 127–33. PMID 9181134.
• Alliel PM, Perin JP, Jollès P, Bonnet FJ (1993). "Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour.". Eur. J. Biochem. 214 (1): 347–50. doi:10.1111/j.1432-1033.1993.tb17930.x. PMID 8389704.
• Bonnet F, Périn JP, Charbonnier F, et al. (1996). "Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells.". J. Biol. Chem. 271 (8): 4373–80. doi:10.1074/jbc.271.8.4373. PMID 8626787.
• Marr HS, Basalamah MA, Edgell CJ (1998). "Endothelial cell expression of testican mRNA.". Endothelium 5 (3): 209–19. doi:10.3109/10623329709053399. PMID 9272383.
• Kohfeldt E, Maurer P, Vannahme C, Timpl R (1997). "Properties of the extracellular calcium binding module of the proteoglycan testican.". FEBS Lett. 414 (3): 557–61. doi:10.1016/S0014-5793(97)01070-3. PMID 9323035.
• Marr HS, Basalamah MA, Bouldin TW, et al. (2001). "Distribution of testican expression in human brain.". Cell Tissue Res. 302 (2): 139–44. doi:10.1007/s004410000277. PMID 11131125.
• BaSalamah MA, Marr HS, Duncan AW, Edgell CJ (2001). "Testican in human blood.". Biochem. Biophys. Res. Commun. 283 (5): 1083–90. doi:10.1006/bbrc.2001.4900. PMID 11355883.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakada M, Miyamori H, Yamashita J, Sato H (2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins.". Cancer Res. 63 (12): 3364–9. PMID 12810672.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
• Prenzel KL, Warnecke-Eberz U, Xi H, et al. (2006). "Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater.". Oncol. Rep. 15 (5): 1397–401. doi:10.3892/or.15.5.1397. PMID 16596217.