SPRY4

Sprouty RTK signaling antagonist 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BUN​
Identifiers
Symbols	SPRY4 ; HH17
External IDs	OMIM: 607984 MGI: 1345144 HomoloGene: 8042 GeneCards: SPRY4 Gene
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • Golgi apparatus • focal adhesion • ruffle membrane Biological process • multicellular organismal development • negative regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81848	24066
Ensembl	ENSG00000187678	ENSMUSG00000024427
UniProt	Q9C004	Q9WTP2
RefSeq (mRNA)	NM_001127496	NM_011898
RefSeq (protein)	NP_001120968	NP_036028
Location (UCSC)	Chr 5: 142.31 – 142.33 Mb	Chr 18: 38.59 – 38.6 Mb
PubMed search

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.^[1][2]

Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[supplied by OMIM]^[2]

See also

• MAPK signaling pathway
• Ras subfamily

Interactions

SPRY4 has been shown to interact with TESK1.^[3]

References

1. Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
2. "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)".
3. Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry / FEBS 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

Further reading

• Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping". BMC Psychiatry 8: 11. doi:10.1186/1471-244X-8-11. PMC 2268687. PMID 18298822.
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
• Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate 66 (6): 613–24. doi:10.1002/pros.20353. PMID 16388505.
• Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology 287 (1): L52–9. doi:10.1152/ajplung.00430.2003. PMID 14977631.
• Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology 5 (5): 427–32. doi:10.1038/ncb978. PMID 12717443.
• Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry / FEBS 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.