SPZ1

Spermatogenic leucine zipper 1
Identifiers
Symbols	SPZ1 ; NYD-TSP1; PPP1R148
External IDs	MGI: 1930801 HomoloGene: 49934 GeneCards: SPZ1 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding Cellular component • nucleus • cytoplasm Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84654	79401
Ensembl	ENSG00000164299	ENSMUSG00000046957
UniProt	Q9BXG8	Q99MY0
RefSeq (mRNA)	NM_032567	NM_030237
RefSeq (protein)	NP_115956	NP_084513
Location (UCSC)	Chr 5: 80.32 – 80.32 Mb	Chr 13: 92.57 – 92.58 Mb
PubMed search

Spermatogenic leucine zipper protein 1 is a protein that in humans is encoded by the SPZ1 gene.^{[1][2][3][4][5][6]}

References

1. Hsu SH, Shyu HW, Hsieh-Li HM, Li H (Feb 2001). "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis". Mech Dev 100 (2): 177–87. doi:10.1016/S0925-4773(00)00513-X. PMID 11165476.
2. Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LL, Wang YQ, Zhou KY (Jun 2003). "Expression of a novel bHLH-Zip gene in human testis". Asian J Androl 5 (2): 83–8. PMID 12778315.
3. Hrabchak C, Varmuza S (Aug 2004). "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis". J Biol Chem 279 (35): 37079–86. doi:10.1074/jbc.M403710200. PMID 15226296.
4. Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (Apr 2005). "Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins". Mol Hum Reprod 11 (4): 307–17. doi:10.1093/molehr/gah163. PMID 15829580.
5. Hsu SH, Hsieh-Li HM, Huang HY, Huang PH, Li H (May 2005). "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis". Cancer Res 65 (10): 4041–50. doi:10.1158/0008-5472.CAN-04-3658. PMID 15899793.
6. "Entrez Gene: SPZ1 spermatogenic leucine zipper 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.