SRCAP

Snf2-related CREBBP activator protein

Identifiers

SRCAP ; DOMO1; EAF1; FLHS; SWR1

External IDs

OMIM: 611421 MGI: 2444036 HomoloGene: 38213 GeneCards: SRCAP Gene

Gene ontology
Molecular function	• DNA binding • transcription coactivator activity • helicase activity • histone acetyltransferase activity • protein binding • ATP binding
Cellular component	• nucleus • nucleoplasm • Golgi apparatus • protein complex • perinuclear region of cytoplasm
Biological process	• transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • viral process • histone acetylation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000080603

ENSMUSG00000053877

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
30.7 – 30.74 Mb

Chr 7:
127.51 – 127.57 Mb

PubMed search

Helicase SRCAP is an enzyme that in humans is encoded by the SRCAP gene.^[1]^[2]^[3]

References

↑ Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J (Jul 1999). "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein". J Biol Chem 274 (23): 16370–6. doi:10.1074/jbc.274.23.16370. PMID 10347196.
↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
↑ "Entrez Gene: SRCAP Snf2-related CBP activator protein".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ghosh AK, Majumder M, Steele R, et al. (2000). "Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP.". J. Biol. Chem. 275 (10): 7184–8. doi:10.1074/jbc.275.10.7184. PMID 10702287.
Xu X, Chackalaparampil I, Monroy MA, et al. (2001). "Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription.". J. Virol. 75 (21): 10033–40. doi:10.1128/JVI.75.21.10033-10040.2001. PMC 114578. PMID 11581372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Monroy MA, Schott NM, Cox L, et al. (2004). "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1.". Mol. Endocrinol. 17 (12): 2519–28. doi:10.1210/me.2003-0208. PMID 14500758.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Eissenberg JC, Wong M, Chrivia JC (2005). "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.". Mol. Cell. Biol. 25 (15): 6559–69. doi:10.1128/MCB.25.15.6559-6569.2005. PMC 1190335. PMID 16024792.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ruhl DD, Jin J, Cai Y, et al. (2006). "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes.". Biochemistry 45 (17): 5671–7. doi:10.1021/bi060043d. PMID 16634648.
Cai Y, Jin J, Gottschalk AJ, et al. (2007). "Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.". Methods 40 (4): 312–7. doi:10.1016/j.ymeth.2006.06.023. PMC 3092633. PMID 17101442.
Wong MM, Cox LK, Chrivia JC (2007). "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters.". J. Biol. Chem. 282 (36): 26132–9. doi:10.1074/jbc.M703418200. PMID 17617668.

External links

OMIM entry on Floating-Harbor syndrome and SRCAP

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