SRD5A3

Steroid 5 alpha-reductase 3
Identifiers
Symbols	SRD5A3 ; CDG1P; CDG1Q; KRIZI; SRD5A2L; SRD5A2L1
External IDs	OMIM: 611715 MGI: 1930252 HomoloGene: 41385 GeneCards: SRD5A3 Gene
EC number	1.3.1.22, 1.3.1.94
Gene ontology Molecular function • 3-oxo-5-alpha-steroid 4-dehydrogenase activity • oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor • cholestenone 5-alpha-reductase activity Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • integral component of membrane Biological process • dolichol-linked oligosaccharide biosynthetic process • dolichyl diphosphate biosynthetic process • androgen biosynthetic process • steroid metabolic process • polyprenol catabolic process • protein N-linked glycosylation via asparagine • dolichol metabolic process • post-translational protein modification • cellular protein metabolic process • small molecule metabolic process • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79644	57357
Ensembl	ENSG00000128039	ENSMUSG00000029233
UniProt	Q9H8P0	Q9WUP4
RefSeq (mRNA)	NM_024592	NM_020611
RefSeq (protein)	NP_078868	NP_065636
Location (UCSC)	Chr 4: 55.35 – 55.37 Mb	Chr 5: 76.14 – 76.16 Mb
PubMed search

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.^[1][2]

See also

• Congenital disorder of glycosylation

References

1. "Entrez Gene: steroid 5 alpha-reductase 3".
2. Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H (January 2008). "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer". Cancer Sci. 99 (1): 81–6. doi:10.1111/j.1349-7006.2007.00656.x. PMID 17986282.

Further reading

• Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.". Endocr. Rev. 25 (6): 947–70. doi:10.1210/er.2003-0030. PMID 15583024.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cantagrel V, Lefeber DJ, Ng BG, et al. (2010). "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.". Cell 142 (2): 203–17. doi:10.1016/j.cell.2010.06.001. PMC 2940322. PMID 20637498.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.