SRGAP3

SLIT-ROBO Rho GTPase activating protein 3
PDB rendering based on 2gnc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2gnc​
Identifiers
Symbols	SRGAP3 ; ARHGAP14; MEGAP; SRGAP2; WRP
External IDs	OMIM: 606525 MGI: 2152938 HomoloGene: 56686 GeneCards: SRGAP3 Gene
Gene ontology Molecular function • GTPase activator activity • protein binding • Rac GTPase binding Cellular component • cytoplasm • cytosol Biological process • small GTPase mediated signal transduction • negative regulation of cell migration • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9901	259302
Ensembl	ENSG00000196220	ENSMUSG00000030257
UniProt	O43295	Q812A2
RefSeq (mRNA)	NM_001033116	NM_080448
RefSeq (protein)	NP_001028289	NP_536696
Location (UCSC)	Chr 3: 8.98 – 9.36 Mb	Chr 6: 112.72 – 112.95 Mb
PubMed search

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.^[1][2]

References

1. Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (Sep 2002). "The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation". Proc Natl Acad Sci U S A 99 (18): 11754–9. doi:10.1073/pnas.162241099. PMC 129341. PMID 12195014.
2. "Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Wong K, Ren XR, Huang YZ, et al. (2001). "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.". Cell 107 (2): 209–21. doi:10.1016/S0092-8674(01)00530-X. PMID 11672528.
• Olave I, Wang W, Xue Y, et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex.". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
• Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Yang Y, Marcello M, Endris V, et al. (2006). "MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation.". Exp. Cell Res. 312 (12): 2379–93. doi:10.1016/j.yexcr.2006.04.001. PMID 16730001.