Serglycin

Serglycin
Identifiers
Symbols	SRGN ; PPG; PRG; PRG1
External IDs	OMIM: 177040 MGI: 97756 HomoloGene: 2043 GeneCards: SRGN Gene
Gene ontology Molecular function • protein binding • collagen binding Cellular component • Golgi membrane • extracellular region • extracellular space • Golgi apparatus • secretory granule • platelet alpha granule lumen • zymogen granule • mast cell granule Biological process • platelet degranulation • blood coagulation • granzyme-mediated apoptotic signaling pathway • protein processing • platelet activation • negative regulation of bone mineralization • biomineral tissue development • mast cell secretory granule organization • protease localization to mast cell secretory granule • T cell secretory granule organization • maintenance of protease location in mast cell secretory granule • maintenance of granzyme B location in T cell secretory granule • negative regulation of cytokine secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5552	19073
Ensembl	ENSG00000122862	ENSMUSG00000020077
UniProt	P10124	P13609
RefSeq (mRNA)	NM_002727	NM_011157
RefSeq (protein)	NP_002718	NP_035287
Location (UCSC)	Chr 10: 69.09 – 69.1 Mb	Chr 10: 62.49 – 62.53 Mb
PubMed search

Serglycin, also known as hematopoetic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene.^[1] It is primarily expressed in hematopoietic cells and endothelial cells.^[2]

Function

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.^[1]

References

1. "Entrez Gene: SRGN serglycin".
2. Kolset, SO; Tveit, H (April 2008). "Serglycin--structure and biology.". Cellular and molecular life sciences : CMLS 65 (7-8): 1073–85. PMID 18066495.

Further reading

• Schick BP (2000). "Regulation of expression of megakaryocyte and platelet proteoglycans.". Stem Cells. 14 Suppl 1: 220–31. doi:10.1002/stem.5530140729. PMID 11012225.
• Humphries DE, Nicodemus CF, Schiller V, Stevens RL (1992). "The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells.". J. Biol. Chem. 267 (19): 13558–63. PMID 1377686.
• Nicodemus CF, Avraham S, Austen KF, et al. (1990). "Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product.". J. Biol. Chem. 265 (10): 5889–96. PMID 2180935.
• Mattei MG, Périn JP, Alliel PM, et al. (1989). "Localization of human platelet proteoglycan gene to chromosome 10, band q22.1, by in situ hybridization.". Hum. Genet. 82 (1): 87–8. doi:10.1007/BF00288281. PMID 2714783.
• Avraham S, Stevens RL, Nicodemus CF, et al. (1989). "Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA.". Proc. Natl. Acad. Sci. U.S.A. 86 (10): 3763–7. doi:10.1073/pnas.86.10.3763. PMC 287220. PMID 2726751.
• Stellrecht CM, Saunders GF (1989). "Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein.". Nucleic Acids Res. 17 (18): 7523. doi:10.1093/nar/17.18.7523. PMC 334837. PMID 2798108.
• Stevens RL, Avraham S, Gartner MC, et al. (1988). "Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells.". J. Biol. Chem. 263 (15): 7287–91. PMID 2835370.
• Périn JP, Bonnet F, Maillet P, Jollès P (1989). "Characterization and N-terminal sequence of human platelet proteoglycan.". Biochem. J. 255 (3): 1007–13. PMC 1135341. PMID 3214420.
• Avraham S, Stevens RL, Gartner MC, et al. (1988). "Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue.". J. Biol. Chem. 263 (15): 7292–6. PMID 3366780.
• Alliel PM, Périn JP, Maillet P, et al. (1988). "Complete amino acid sequence of a human platelet proteoglycan.". FEBS Lett. 236 (1): 123–6. doi:10.1016/0014-5793(88)80298-9. PMID 3402609.
• Hatton MN, Loomis RE, Levine MJ, Tabak LA (1985). "Masticatory lubrication. The role of carbohydrate in the lubricating property of a salivary glycoprotein-albumin complex.". Biochem. J. 230 (3): 817–20. PMC 1152688. PMID 4062880.
• Schick BP, Jacoby JA (1995). "Serglycin and betaglycan proteoglycans are expressed in the megakaryocytic cell line CHRF 288-11 and normal human megakaryocytes.". J. Cell. Physiol. 165 (1): 96–106. doi:10.1002/jcp.1041650113. PMID 7559813.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Kolset SO, Mann DM, Uhlin-Hansen L, et al. (1996). "Serglycin-binding proteins in activated macrophages and platelets.". J. Leukoc. Biol. 59 (4): 545–54. PMID 8613703.
• Toyama-Sorimachi N, Kitamura F, Habuchi H, et al. (1997). "Widespread expression of chondroitin sulfate-type serglycins with CD44 binding ability in hematopoietic cells.". J. Biol. Chem. 272 (42): 26714–9. doi:10.1074/jbc.272.42.26714. PMID 9334256.
• Galvin JP, Spaeny-Dekking LH, Wang B, et al. (1999). "Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.". J. Immunol. 162 (9): 5345–50. PMID 10228010.
• Schick BP, Gradowski JF, San Antonio JD (2001). "Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells.". Blood 97 (2): 449–58. doi:10.1182/blood.V97.2.449. PMID 11154222.
• Omtvedt LA, Kolset SO, Thoen J, et al. (2001). "Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases.". Scand. J. Rheumatol. 30 (3): 164–6. doi:10.1080/030097401300162941. PMID 11469527.
• Metkar SS, Wang B, Aguilar-Santelises M, et al. (2002). "Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.". Immunity 16 (3): 417–28. doi:10.1016/S1074-7613(02)00286-8. PMID 11911826.