SRPX

Sushi-repeat containing protein, X-linked
Identifiers
Symbols	SRPX ; DRS; ETX1; HEL-S-83p; SRPX1
External IDs	OMIM: 300187 MGI: 1858306 HomoloGene: 4598 GeneCards: SRPX Gene
Gene ontology Molecular function • protein binding Cellular component • autophagosome • endoplasmic reticulum • cell surface • membrane Biological process • phagolysosome assembly • autophagy • cell adhesion • response to endoplasmic reticulum stress • negative regulation of cell proliferation involved in contact inhibition • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8406	51795
Ensembl	ENSG00000101955	ENSMUSG00000090084
UniProt	P78539	Q9R0M3
RefSeq (mRNA)	NM_001170750	NM_016911
RefSeq (protein)	NP_001164221	NP_058607
Location (UCSC)	Chr X: 38.15 – 38.22 Mb	Chr X: 10.04 – 10.12 Mb
PubMed search

Sushi repeat-containing protein SRPX is a protein that in humans is encoded by the SRPX gene.^[1][2][3] Bioinformatics analysis suggests the SRPX protein is a peroxiredoxin. ^[4]

References

1. Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T (Jul 1996). "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa". Hum Mol Genet 4 (12): 2339–46. doi:10.1093/hmg/4.12.2339. PMID 8634708.
2. Dry KL, Aldred MA, Edgar AJ, Brown J, Manson FD, Ho MF, Prosser J, Hardwick LJ, Lennon AA, Thomson K, et al. (Jul 1996). "Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retintis pigmentosa (RP3)". Hum Mol Genet 4 (12): 2347–53. doi:10.1093/hmg/4.12.2347. PMID 8634709.
3. "Entrez Gene: SRPX sushi-repeat-containing protein, X-linked".
4. Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins.". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

Further reading

• Nangaku M, Shankland SJ, Kurokawa K, et al. (1997). "Cloning of a new human gene with short consensus repeats using the EST database.". Immunogenetics 46 (2): 99–103. doi:10.1007/s002510050247. PMID 9162095.
• Shimakage M, Takami K, Kodama K, et al. (2002). "Expression of drs mRNA in human lung adenocarcinomas.". Hum. Pathol. 33 (6): 615–9. doi:10.1053/hupa.2002.125373. PMID 12152160.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Mukaisho K, Suo M, Shimakage M, et al. (2003). "Down-regulation of drs mRNA in colorectal neoplasms.". Jpn. J. Cancer Res. 93 (8): 888–93. doi:10.1111/j.1349-7006.2002.tb01334.x. PMID 12716466.
• Kim CJ, Shimakage M, Kushima R, et al. (2003). "Down-regulation of drs mRNA in human prostate carcinomas.". Hum. Pathol. 34 (7): 654–7. doi:10.1016/S0046-8177(03)00240-5. PMID 12874760.
• Tambe Y, Isono T, Haraguchi S, et al. (2004). "A novel apoptotic pathway induced by the drs tumor suppressor gene.". Oncogene 23 (17): 2977–87. doi:10.1038/sj.onc.1207419. PMID 15021917.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.