SRPX2

Sushi-repeat containing protein, X-linked 2
Identifiers
Symbols	SRPX2 ; BPP; CBPS; PMGX; RESDX; SRPUL
External IDs	OMIM: 300642 MGI: 1916042 HomoloGene: 8704 GeneCards: SRPX2 Gene
Gene ontology Molecular function • receptor binding • protein binding • hepatocyte growth factor binding • identical protein binding Cellular component • extracellular space • cytoplasm • cell surface • cell junction • excitatory synapse • synaptic membrane Biological process • angiogenesis • single organismal cell-cell adhesion • regulation of phosphorylation • cell motility • positive regulation of synapse assembly • vocalization behavior • positive regulation of cell migration involved in sprouting angiogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27286	68792
Ensembl	ENSG00000102359	ENSMUSG00000031253
UniProt	O60687	Q8R054
RefSeq (mRNA)	NM_014467	NM_001083895
RefSeq (protein)	NP_055282	NP_001077364
Location (UCSC)	Chr X: 100.64 – 100.67 Mb	Chr X: 133.91 – 133.93 Mb
PubMed search

Sushi repeat-containing protein SRPX2 is a protein that in humans is encoded by the SRPX2 gene.^[1][2] Bioinformatics analysis suggests the SRPX2 protein is a peroxiredoxin. ^[3]

References

1. Kurosawa H, Goi K, Inukai T, Inaba T, Chang KS, Shinjyo T, Rakestraw KM, Naeve CW, Look AT (Feb 1999). "Two candidate downstream target genes for E2A-HLF". Blood 93 (1): 321–32. PMID 9864177.
2. "Entrez Gene: SRPX2 sushi-repeat-containing protein, X-linked 2".
3. Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi:10.1186/1471-2164-11-590. PMC 3091736. PMID 20964819.

Further reading

• Suzuki Y, Taira H, Tsunoda T, et al. (2001). "Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites". EMBO Rep. 2 (5): 388–93. doi:10.1093/embo-reports/kve085. PMC 1083880. PMID 11375929.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Roll P, Rudolf G, Pereira S, et al. (2006). "SRPX2 mutations in disorders of language cortex and cognition". Hum. Mol. Genet. 15 (7): 1195–207. doi:10.1093/hmg/ddl035. PMID 16497722.
• Royer B, Soares DC, Barlow PN, et al. (2008). "Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas". BMC Genet. 8: 72. doi:10.1186/1471-2156-8-72. PMC 2151080. PMID 17942002.