SSPO
| SCO-spondin | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SSPO ; SCO-spondin | ||||||||||||
| External IDs | MGI: 2674311 HomoloGene: 45453 GeneCards: SSPO Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23145 | 243369 | |||||||||||
| Ensembl | ENSG00000197558 | ENSMUSG00000029797 | |||||||||||
| UniProt | A2VEC9 | Q8CG65 | |||||||||||
| RefSeq (mRNA) | NM_198455 | NM_173428 | |||||||||||
| RefSeq (protein) | NP_940857 | NP_775604 | |||||||||||
| Location (UCSC) |
Chr 7: 149.78 – 149.83 Mb |
Chr 6: 48.45 – 48.5 Mb | |||||||||||
| PubMed search | |||||||||||||
SCO-spondin is a protein that in humans is encoded by the SSPO gene.[1][2][3] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.[4]
References
- ↑ Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (Dec 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". J Cell Sci. 109. ( Pt 5): 1053–61. PMID 8743952.
- ↑ Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (Nov 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217.
- ↑ "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".
- ↑ Gobron, S.; Creveaux, I.; Meiniel, R.; Didier, R.; Dastugue, B.; Meiniel, A. (1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience 88 (2): 655–664. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783.
Further reading
- Meiniel A, Meiniel R, Gonçalves-Mendes N, et al. (2004). "The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines.". Int. Rev. Cytol. 230: 1–39. doi:10.1016/S0074-7696(03)30001-4. PMID 14692680.
- Meiniel O, Meiniel A (2007). "The complex multidomain organization of SCO-spondin protein is highly conserved in mammals.". Brain Research Reviews 53 (2): 321–7. doi:10.1016/j.brainresrev.2006.09.007. PMID 17126404.
- Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gonçalves-Mendes N, Simon-Chazottes D, Creveaux I, et al. (2003). "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain.". Gene 312: 263–70. doi:10.1016/S0378-1119(03)00622-X. PMID 12909363.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gonçalves-Mendes N, Blanchon L, Meiniel A, et al. (2004). "Placental expression of SCO-spondin during mouse and human development.". Gene Expr. Patterns 4 (3): 309–14. doi:10.1016/j.modgep.2003.10.004. PMID 15053980.
- Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
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