SSR2

Signal sequence receptor, beta (translocon-associated protein beta)
Identifiers
Symbols	SSR2 ; HSD25; TLAP; TRAP-BETA; TRAPB
External IDs	OMIM: 600867 MGI: 1913506 HomoloGene: 2369 GeneCards: SSR2 Gene
Gene ontology Molecular function • signal sequence binding Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • integral component of membrane Biological process • translation • cotranslational protein targeting to membrane • SRP-dependent cotranslational protein targeting to membrane • gene expression • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6746	66256
Ensembl	ENSG00000163479	ENSMUSG00000041355
UniProt	P43308	Q9CPW5
RefSeq (mRNA)	NM_003145	NM_025448
RefSeq (protein)	NP_003136	NP_079724
Location (UCSC)	Chr 1: 156.01 – 156.02 Mb	Chr 3: 88.58 – 88.59 Mb
PubMed search

Translocon-associated protein subunit beta also known as TRAP-beta is a protein that in humans is encoded by the SSR2 gene.^[1][2]

Function

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23.^[2]

References

1. Chinen K, Sudo K, Takahashi E, Nakamura Y (Jul 1995). "Isolation and mapping of the human beta-signal sequence receptor gene (SSR2)". Cytogenet Cell Genet 70 (3–4): 215–7. doi:10.1159/000134036. PMID 7789174.
2. "Entrez Gene: SSR2 signal sequence receptor, beta (translocon-associated protein beta)".

Further reading

• Tajima S, Lauffer L, Rath VL, Walter P (1986). "The signal recognition particle receptor is a complex that contains two distinct polypeptide chains". J. Cell Biol. 103 (4): 1167–78. doi:10.1083/jcb.103.4.1167. PMC 2114348. PMID 3021779.
• Hartmann E, Görlich D, Kostka S, et al. (1993). "A tetrameric complex of membrane proteins in the endoplasmic reticulum". Eur. J. Biochem. 214 (2): 375–81. doi:10.1111/j.1432-1033.1993.tb17933.x. PMID 7916687.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bodescot M, Brison O (1994). "Cloning and sequence analysis of the beta subunit of the human translocon-associated protein". Biochim. Biophys. Acta 1217 (1): 101–2. doi:10.1016/0167-4781(94)90131-7. PMID 8286409.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang L, Dobberstein B (1999). "Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum". FEBS Lett. 457 (3): 316–22. doi:10.1016/S0014-5793(99)01075-3. PMID 10471800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.