SSX2IP

Synovial sarcoma, X breakpoint 2 interacting protein
Identifiers
Symbols	SSX2IP ; ADIP
External IDs	OMIM: 608690 MGI: 2139150 HomoloGene: 8522 GeneCards: SSX2IP Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • adherens junction • cell leading edge • centriolar satellite • ciliary basal body • protein complex Biological process • cell adhesion • regulation of Rac protein signal transduction • intraciliary transport involved in cilium morphogenesis • cilium assembly • centrosome organization • regulation of cell motility Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	117178	99167
Ensembl	ENSG00000117155	ENSMUSG00000036825
UniProt	Q9Y2D8	Q8VC66
RefSeq (mRNA)	NM_001166293	NM_001253768
RefSeq (protein)	NP_001159765	NP_001240697
Location (UCSC)	Chr 1: 84.64 – 84.69 Mb	Chr 3: 146.4 – 146.44 Mb
PubMed search

Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the SSX2IP gene.^[1]

Interactions

SSX2IP has been shown to interact with MLLT4^[2] and Actinin, alpha 1.^[2]

References

1. "Entrez Gene: SSX2IP synovial sarcoma, X breakpoint 2 interacting protein".
2. Asada, Masanori; Irie Kenji; Morimoto Koji; Yamada Akio; Ikeda Wataru; Takeuchi Masakazu; Takai Yoshimi (Feb 2003). "ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions". J. Biol. Chem. (United States) 278 (6): 4103–11. doi:10.1074/jbc.M209832200. ISSN 0021-9258. PMID 12446711.

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• de Bruijn DR, dos Santos NR, Kater-Baats E, et al. (2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes Chromosomes Cancer 34 (3): 285–98. doi:10.1002/gcc.10073. PMID 12007189. replacement character in |first7= at position 6 (help); replacement character in |first4= at position 4 (help)
• Asada M, Irie K, Morimoto K, et al. (2003). "ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions". J. Biol. Chem. 278 (6): 4103–11. doi:10.1074/jbc.M209832200. PMID 12446711.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Guinn BA, Bland EA, Lodi U, et al. (2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochem. Biophys. Res. Commun. 335 (4): 1293–304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.