SSX5
| Synovial sarcoma, X breakpoint 5 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SSX5 ; MGC9494 | ||||||||||||
| External IDs | OMIM: 300327 HomoloGene: 137346 GeneCards: SSX5 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6758 | 67985 | |||||||||||
| Ensembl | ENSG00000165583 | ENSMUSG00000079705 | |||||||||||
| UniProt | O60225 | Q9CPU1 | |||||||||||
| RefSeq (mRNA) | NM_021015 | NM_026492.3 | |||||||||||
| RefSeq (protein) | NP_066295 | NP_080768.1 | |||||||||||
| Location (UCSC) |
Chr X: 48.19 – 48.28 Mb |
Chr X: 7.99 – 8 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.[1]
Function
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.[1]
References
Further reading
- dos Santos NR, de Bruijn DR, van Kessel AG (2001). "Molecular mechanisms underlying human synovial sarcoma development". Genes Chromosomes Cancer 30 (1): 1–14. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G. PMID 11107170.
- Gure AO, Türeci O, Sahin U, et al. (1997). "SSX: a multigene family with several members transcribed in normal testis and human cancer". Int. J. Cancer 72 (6): 965–71. doi:10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N. PMID 9378559.
- Chen CH, Chen GJ, Lee HS, et al. (2001). "Expressions of cancer-testis antigens in human hepatocellular carcinomas". Cancer Lett. 164 (2): 189–95. doi:10.1016/S0304-3835(01)00379-2. PMID 11179834.
- de Bruijn DR, dos Santos NR, Kater-Baats E, et al. (2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes Chromosomes Cancer 34 (3): 285–98. doi:10.1002/gcc.10073. PMID 12007189. replacement character in
|first7=at position 6 (help); replacement character in|first4=at position 4 (help) - Güre AO, Wei IJ, Old LJ, Chen YT (2002). "The SSX gene family: characterization of 9 complete genes". Int. J. Cancer 101 (5): 448–53. doi:10.1002/ijc.10634. PMID 12216073.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Wu LQ, Lu Y, Wang XF, et al. (2006). "Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma". Life Sci. 79 (8): 744–8. doi:10.1016/j.lfs.2006.02.024. PMID 16546222.
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