STARD10

StAR-related lipid transfer (START) domain containing 10
Identifiers
Symbols	STARD10 ; CGI-52; NY-CO-28; PCTP2; SDCCAG28
External IDs	MGI: 1860093 HomoloGene: 4841 GeneCards: STARD10 Gene
Gene ontology Molecular function • protein binding • lipid binding Cellular component • cytosol • microvillus • membrane • intercellular canaliculus Biological process • bile acid secretion • positive regulation of peroxisome proliferator activated receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10809	56018
Ensembl	ENSG00000214530	ENSMUSG00000030688
UniProt	Q9Y365	Q9JMD3
RefSeq (mRNA)	NM_006645	NM_019990
RefSeq (protein)	NP_006636	NP_064374
Location (UCSC)	Chr 11: 72.75 – 72.79 Mb	Chr 7: 101.32 – 101.35 Mb
PubMed search

StAR-related lipid transfer protein 10 (STARD10) or PCTP-like protein is a lipid transfer protein that in humans is encoded by the STARD10 gene.^[1][2] The protein derives its name from the fact that the molecule contains a START domain. As part of the StarD2 subfamily, StarD10 can transport the lipids phosphatidylcholine and phosphatidylethanolamine between membranes in solution.^[3] Casein kinase II phosphorylates the protein on its serine at position 184.^[4]

The function of StarD10 in the cell is not yet understood. Its expression is associated with cancer, but the nature of its role is unclear. Most recent data indicate that loss of StarD10 expression in breast cancer is associated with poor outcomes in patients.^[5]

References

1. Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
2. "Entrez Gene: STARD10 START domain containing 10".
3. Olayioye MA, Vehring S, Müller P, Herrmann A, Schiller J, Thiele C, Lindeman GJ, Visvader JE, Pomorski T (Jul 2005). "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein". J Biol Chem 280 (29): 27436–42. doi:10.1074/jbc.M413330200. PMID 15911624.
4. Olayioye MA, Buchholz M, Schmid S, Schöffler P, Hoffmann P, Pomorski T (Aug 2007). "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity". J Biol Chem 282 (31): 22492–8. doi:10.1074/jbc.M701990200. PMID 17561512.
5. Murphy NC, Biankin AV, Millar EK, McNeil CM, O'Toole SA, Segara D, Crea P, Olayioye MA, Lee CS, Fox SB, Morey AL, Christie M, Musgrove EA, Daly RJ, Lindeman GJ, Henshall SM, Visvader JE, Sutherland RL (Mar 2010). "Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status". Int J Cancer 126 (6): 1445–53. doi:10.1002/ijc.24826. PMID 19676041.

Further reading

• Olayioye MA, Buchholz M, Schmid S, et al. (2007). "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity". J. Biol. Chem. 282 (31): 22492–8. doi:10.1074/jbc.M701990200. PMID 17561512.
• Olayioye MA, Vehring S, Müller P, et al. (2005). "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein". J. Biol. Chem. 280 (29): 27436–42. doi:10.1074/jbc.M413330200. PMID 15911624.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Tabibiazar R, Wagner RA, Liao A, Quertermous T (2004). "Transcriptional profiling of the heart reveals chamber-specific gene expression patterns". Circ. Res. 93 (12): 1193–201. doi:10.1161/01.RES.0000103171.42654.DD. PMID 14576202.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.