STARD7
| StAR-related lipid transfer (START) domain containing 7 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | STARD7 ; GTT1 | ||||||||||||
| External IDs | MGI: 2139090 HomoloGene: 32463 GeneCards: STARD7 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 56910 | 99138 | |||||||||||
| Ensembl | ENSG00000084090 | ENSMUSG00000027367 | |||||||||||
| UniProt | Q9NQZ5 | Q8R1R3 | |||||||||||
| RefSeq (mRNA) | NM_020151 | NM_139308 | |||||||||||
| RefSeq (protein) | NP_064536 | NP_647469 | |||||||||||
| Location (UCSC) |
Chr 2: 96.18 – 96.21 Mb |
Chr 2: 127.27 – 127.3 Mb | |||||||||||
| PubMed search | |||||||||||||
StAR-related lipid transfer domain protein 7 (STARD7) or gestational trophoblastic tumor gene-1 (GTT1) is a lipid transporter that specifically binds and transports phosphatidylcholine between membranes.[1]
Function and tissue distribution
StarD7 is found in the cytosol and associated with the mitochondrion.[1] When overproduced in the cell, mitochondrial levels of phosphatidylcholine rise.[1] High levels of the protein are found in tumor cells compared to normal cells, suggesting a role in cell proliferation.[2]
Structure
There are two forms of StarD7: StarD7-I and StarD7-II. The former is 295 amino acids long. StarD7-I possesses an additional 75 amino acids at its amino-terminus, which form a signaling sequence that targets it to the outer membrane of the mitochondrion.[1]
StarD7 contains a StAR-related transfer domain (START), from which it derives its name. Moreover, the protein is a member of the predominantly phosphatidylcholine transporter subfamily of START proteins, the StarD2 subfamily. It shares 25% sequence identity with StarD2.[1]
References
- 1 2 3 4 5 Horibata Y, Sugimoto H (March 2010). "StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria". J. Biol. Chem. 285 (10): 7358–65. doi:10.1074/jbc.M109.056960. PMC 2844184. PMID 20042613.
- ↑ Durand S, Angeletti S, Genti-Raimondi S (January 2004). "GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization". Placenta 25 (1): 37–44. doi:10.1016/S0143-4004(03)00214-5. PMID 15013637.