STEAP2

STEAP family member 2, metalloreductase
Identifiers
Symbols	STEAP2 ; IPCA1; PCANAP1; PUMPCn; STAMP1; STMP
External IDs	OMIM: 605094 MGI: 1921301 HomoloGene: 17682 GeneCards: STEAP2 Gene
Gene ontology Molecular function • transporter activity • cupric reductase activity • metal ion binding • ferric-chelate reductase (NADPH) activity Cellular component • early endosome • cytosol • plasma membrane • integral component of plasma membrane • endosome membrane • trans-Golgi network transport vesicle • integral component of Golgi membrane • intracellular membrane-bounded organelle Biological process • Golgi to plasma membrane transport • endocytosis • response to hormone • copper ion import • regulated secretory pathway • iron ion homeostasis • oxidation-reduction process • ferric iron import into cell Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	261729	74051
Ensembl	ENSG00000157214	ENSMUSG00000015653
UniProt	Q8NFT2	Q8BWB6
RefSeq (mRNA)	NM_001040665	NM_001103156
RefSeq (protein)	NP_001035755	NP_001096626
Location (UCSC)	Chr 7: 90.17 – 90.24 Mb	Chr 5: 5.66 – 5.69 Mb
PubMed search

Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2 gene.^[1][2][3]

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[3]

References

1. Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (Jan 2000). "Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes". Genome Res 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC 310991. PMID 10613842.
2. Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
3. "Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2".

Further reading

• Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.
• Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006). "The Steap proteins are metalloreductases". Blood 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC 1785011. PMID 16609065.
• Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID 15897894.
• Sanchez-Pulido L, Rojas AM, Valencia A, et al. (2005). "ACRATA: a novel electron transfer domain associated to apoptosis and cancer". BMC Cancer 4: 98. doi:10.1186/1471-2407-4-98. PMC 546010. PMID 15623366.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Porkka KP, Helenius MA, Visakorpi T (2002). "Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate". Lab. Invest. 82 (11): 1573–82. doi:10.1097/01.lab.0000038554.26102.c6. PMID 12429817.