STK17A

Serine/threonine kinase 17a
Identifiers
Symbols	STK17A ; DRAK1
External IDs	OMIM: 604726 HomoloGene: 55846 GeneCards: STK17A Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • ATP binding Cellular component • nucleus Biological process • protein phosphorylation • apoptotic process • intracellular signal transduction • positive regulation of apoptotic process • positive regulation of fibroblast apoptotic process • regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9263	n/a
Ensembl	ENSG00000164543	n/a
UniProt	Q9UEE5	n/a
RefSeq (mRNA)	NM_004760	n/a
RefSeq (protein)	NP_004751	n/a
Location (UCSC)	Chr 7: 43.58 – 43.63 Mb	n/a
PubMed search		n/a

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene. ^[1]

Function

This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AB011420.1, BC047696.1 [ECO:0000332] RNAseq introns  :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END##

References

1. "Entrez Gene: Serine/threonine kinase 17a". Retrieved 2014-04-11.

Further reading

• Landa, I; Ruiz-Llorente, S; Montero-Conde, C; Inglada-Pérez, L; Schiavi, F; Leskelä, S; Pita, G; Milne, R; Maravall, J; Ramos, I; Andía, V; Rodríguez-Poyo, P; Jara-Albarrán, A; Meoro, A; Del Peso, C; Arribas, L; Iglesias, P; Caballero, J; Serrano, J; Picó, A; Pomares, F; Giménez, G; López-Mondéjar, P; Castello, R; Merante-Boschin, I; Pelizzo, M. R.; Mauricio, D; Opocher, G; Rodríguez-Antona, C; et al. (2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLoS Genetics 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
• Sanjo, H; Kawai, T; Akira, S (1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry 273 (44): 29066–71. doi:10.1074/jbc.273.44.29066. PMID 9786912.
• Mao, P; Hever, M. P.; Niemaszyk, L. M.; Haghkerdar, J. M.; Yanco, E. G.; Desai, D; Beyrouthy, M. J.; Kerley-Hamilton, J. S.; Freemantle, S. J.; Spinella, M. J. (2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". Journal of Biological Chemistry 286 (22): 19381–91. doi:10.1074/jbc.M111.218040. PMC 3103316. PMID 21489989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.